The Buffalo Bills (7-1) and New York Jets (2-7) meet Sunday in East Rutherford, New Jersey, for a Week 10 AFC East battle. Kickoff from MetLife Stadium is at 1 p.m. ET (CBS). Let's analyze NFL odds around the Bills vs. Jets odds and make our expert NFL picks and predictions for the best bets.
These AFC East foes have had to wait until now to meet for the first time this season. This year has gone in opposite directions for these 2 as most expected. Their recent form represents that.
Buffalo is on a 4-game winning streak, most recently beating the Minnesota Vikings 23-6 on Monday Night Football. The Bills rode RB James Cook to victory with his 31 carries for 107 yards and a TD. QB Josh Allen was 21 of 31 passing for 234 yards with a TD and INT.
The script for the Bills has been simple this season: Outscore everyone, whether that means leaning on Allen or leaning on Cook. It has worked, but eyes in Buffalo will be on their defense this week as the team landed S Amani Hooker in a deal with the Tennessee Titans at the 2026 NFL trade deadline this week. There are high hopes for Hooker and his potential to improve a below average secondary.
Meanwhile, the Jets have lost 4 in a row heading into Sunday. Last week, New York was down only 14-12 to the Kansas City Chiefs at halftime before being blown out in the second half in a 35-12 loss.
Some expected the Jets to be sellers at the trade deadline but the team was not. New York held onto the likes of QB Geno Smith, RB Breece Hall, WR Garrett Wilson and DE Will McDonald, all of which saw their names in trade rumors and speculation.
While more of those names are players from of the offensive side of the ball, the Jets offense has held up their end of the bargain in recent weeks. Instead, coach Aaron Glenn has seen his defense falter, putting him squarely on the hot seat in New York. The Jets have allowed 24.8 points per game, ranking 22nd in the NFL.
Buffalo is 6-2 against the spread (ATS) and 5-3 on point totals this year. The Jets have kept plenty of games close but are just 4-5 ATS and have that same record on points. The Bills have won 5 straight games in this AFC East rivalry.
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Bills at Jets odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 7:46 p.m. ET.
- Moneyline (ML): Bills -450 (bet $450 to win $100) | Jets +340 (bet $100 to win $340)
- Against the spread (ATS): Bills -7.5 (-110) | Jets +7.5 (-108)
- Over/Under (O/U): 51 (O: -108 | U: -110)
Bills at Jets injuries
Bills
- OL Spencer Brown (ankle) doubtful
- CB Christian Benford (wrist) questionable
- DB Sam Franklin (shoulder) questionable
Jets
- CB Jarvis Brownlee Jr. (illness) questionable
- WR Omar Cooper Jr. (ankle) questionable
- ED Joseph Ossai (ankle) questionable
- WR Adonai Mitchell (knee) questionable
- DL Harrison Phillips (ankle) questionable
- WR Garrett Wilson (concussion) questionable
- LB Trevin Wallace (groin) out
- CB Nahshon Wright (back) questionable
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Bills at Jets picks and predictions
Prediction
Bills 34, Jets 20
Moneyline
PASS.
There is simply no value at all for the Bills (-450) on the moneyline.
Against the spread
BET BILLS -7.5 (-110).
The Bills have been rolling and the Jets have not. Don't overthink this.
The bigger factor comes from New York's side of the ledger. The Jets offense has shown they can put some points up on occasion and Buffalo does not sport the most threatening defense and still don't even with the addition of Hooker.
What is concerning is the level of "quit" the Jets have shown, especially on defense, under Glenn's watch. The high-powered Bills offense could make that happen again.
Over/Under
LEAN OVER 51 (-110).
It's a crazy number to predict the over, but 34 might be too nice of a total in regard to the Jets on defense. The Bills have rolled in games with either Allen or Cook and this game lines up as one that could have both producing from start to finish. Buffalo enters Week 10 leading the NFL in both yards per game (386.4) and points per game (32.0).
Best prop bet
Buffalo QB JOSH ALLEN ANYTIME TD (-170).
Shockingly, the Bills won last week without Allen scoring. With a Buffalo explosion on offense predicted here, there is no reason to think Allen won't be involved in getting one into the end zone. Allen not getting into the end zone a week ago was an outlier as well. It was just the second time this season he did not have a rushing touchdown in a game.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Buffalo Bills at New York Jets odds, picks and predictions
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