The LA Clippers (1-0) and Los Angeles Lakers (1-0) meet Friday at Crypto.com Arena in Los Angeles, California. Tip-off is set for 10 p.m. ET. Let's analyze NBA odds around the Clippers vs. Lakers odds and make our expert NBA picks and predictions for the best bets.
2025-26 season series: Tied 2-2; the home team was 4-0 straight up (SU) and against the spread (ATS) last season, with the Over cashed in both meetings at Crypto.com Arena.
The Clippers opened the season Wednesday with a 121-96 victory as a 2.5-point home underdog against the Sacramento Kings as the Under (232.5) cashed. G Darius Garland went for 30 points on 11 of 19 from the field, and 3 of 8 from behind the arc, while C Brook Lopez came off the bench to post 17 points and 11 rebounds
with a block and a steal.
The Lakers pounded the Golden State Warriors 127-105 Wednesday as a 17.5-point favorite as the Over (229.5) connected. Los Angeles had 3 players score 23+ points, including G Luka Doncic, who finished with a team-best 28 points, 8 rebounds, 6 assists and 3 steals, while hitting 5 3-pointers. C Walker Kessler was perfect from the field (12 of 12 ), finishing with 26 points and 9 rebounds with 2 blocks, while G Austin Reaves ended up with 23 points.
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Clippers at Lakers odds
Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 3:02 p.m. ET.
- Moneyline (ML): Clippers +300 (bet $100 to win $300) | Lakers -375 (bet $375 to win $100)
- Against the spread (ATS): Clippers +9.5 (-112) | Lakers -9.5 (-108)
- Over/Under (O/U): 225.5 (O: -110 | U: -110)
Clippers at Lakers key injuries
Clippers
- G Bradley Beal (knee) out
- F Brandon Ingram (heel) out
- G Jordan Miller (shoulder) out
- C Yanic Konan Niederhauser (foot) out
- G Max Strus (foot) out
Lakers
- G Cameron Carr (oblique) out
- C Walker Kessler (finger) available
- G Jake LaRavia (ankle) questionable
- F Adou Thiero (knee) out
For most recent updates: Official NBA injury report.
Clippers at Lakers picks and predictions
Prediction
Lakers 121, Clippers 106
Moneyline
The Lakers (-375) will cost you nearly 4 times your potential return, and that's way too much to bet on a straight up play. Even if you were to including the Lakers in a multi-leg parlay, that would kill a lot of the value of your ticket.
AVOID, and look to the spread instead.
Against the spread
The LAKERS -9.5 (-108) should be able to get it done by double digits.
The Clippers overproduced against a Kings team which is projected to be one of the worst teams in the NBA, with the Clips not far behind. The Lakers are deeper, and they have a few more prolific scorers. And, really, Doncic is good enough to get the Lakers there themselves.
Over/Under
LEAN OVER 225.5 (-110), but go with a half-unit play at most.
The Over cashed in the first game for the Lakers, with L.A. racking up 127 points. The purple and gold should be able to pile up another strong amount of points against the undermanned Clippers, too.
Best prop bet
Let's go with Lakers G LUKA DONCIC OVER 47.5 POINTS+REBOUNDS+ASSISTS (-118).
Play Luka combos is just a fun time. He racks up points, rebounds and assists at a high, frequent rate, and betting should be fun sometimes. Against the Clippers, Doncic will have plenty of room to cook.
Betting odds calculator
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow Daniel Dobish on X at @danieledobish. Follow SportsbookWire on X at SportsBookWire and on Facebook.
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This article originally appeared on Sportsbook Wire: LA Clippers at Los Angeles Lakers odds, picks and predictions
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