The Minnesota Twins (69-76) and Detroit Tigers (66-79) close out their 3-game series in Detroit, Michigan, Wednesday. First pitch from Comerica Park is at 1:10 p.m. ET. Let's analyze MLB odds around the Twins vs. Tiger odds and make our expert MLB picks and predictions for the best bets.
Season series: Twins lead 8-4
The Twins have lost 4 of their last 6 games and 8 of their last 13. They snapped a 2-game skid Tuesday with a 3-2 win as +113 underdogs with the Under (8.5) cashing. 2B-LF Kody Clemens hit a 2-run home run in the sixth inning to give them the lead, and the bullpen gave them 4 innings of hitless relief to hold on for the win.
The Tigers have lost 4 of 6 and 15 of their last 20 games. They were -136 favorites in the loss on Tuesday.
2B-LF Kevin McGonigle hit a 2-run shot in the fifth inning to give the Tigers the lead, but they didn't get another hit.
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Twins at Tigers projected starters
RHP Zebby Matthews vs. RHP Keider Montero
Matthews (9-9, 4.69 ERA) makes his 21st start. He has a 1.25 WHIP, 2.5 BB/9 and 7.5 K/9 in 117 innings.
- Last start: Loss, 5 IP, 4 ER, 4 H, 1 BB, 4 K in 4-1 home loss to Chicago White Sox Friday
- Last start vs. Tigers (June 11): Loss, 6 IP, 7 ER, 9 H, 1 BB, 4 K in 11-0 loss in Detroit
- Career vs. Tigers: 1-1, 6.00 ERA (15 IP, 10 ER), 1.67 WHIP, 9.6 K/9 in 3 starts
- 2026 road splits: 4-5, 6.45 ERA (60 IP, 43 ER), 1.38 WHIP, 9.3 K/9 in 11 starts
Montero (9-8, 3.52 ERA) makes his 24th start and 30th appearance. He has a 1.03 WHIP, 2.0 BB/9 and 6.0 K/9 in 143 innings.
- Last start: No-decision, 4 IP, 6 ER, 8 H, 1 BB, 4 K in 7-6 loss at Cleveland Guardians Friday
- Last start vs. Twins (June 11): Win, 6 1/3 IP, 0 ER, 4 H, 1 BB, 4 K in 11-0 win in Detroit
- Career vs. Twins: 2-1, 3.57 ERA (17 2/3 IP, 7 ER), 1.19 WHIP, 6.6 K/9 in 3 starts
- 2026 home splits: 5-4, 3.38 ERA (85 1/3 IP, 32 ER), 1.10 WHIP, 5.2 K/9 in 16 games (14 starts)
Twins at Tigers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:41 a.m. ET.
- Moneyline (ML): Twins +110 (bet $100 to win $110) | Tigers -135 (bet $135 to win $100)
- Run line (RL)/Against the spread (ATS): Twins +1.5 (-200) | Tigers -1.5 (+165)
- Over/Under (O/U): 8.5 (O: -115 | U: -105)
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Twins at Tigers picks and predictions
Prediction
Twins 5, Tigers 4
Moneyline
The Twins have won 8 of 12 games in the series so far. They have won 6 of Matthews' last 7 starts. But since June 21, the Tigers have not lost consecutive Montero starts, and they lost his last start.
The Twins are only 30-42 on the road, but the Tigers are only 35-35 at home.
We are going with the Twins having the advantage, having won 6 of Matthews' last 7 starts.
BET TWINS (+110).
Run line/Against the spread
Eleven of the Twins' last 12 covers have been outright wins. The Tigers are 15-25 ATS as home favorites, per Teamrankings.com.
The plus odds on the Twins ML make that the better play for this game.
PASS.
Over/Under
Six of the Twins' last 8 games have had totals of 9 or more. Nine of the 12 meetings this season have had totals of 9 or more. The Over is 7-1 in their last 8 meetings.
BET OVER 8.5 (-115).
Best prop bet
Zebby Matthews OVER 4.5 strikeouts (+115)
He has had 5 or more strikeouts in half of his 20 starts, and in 2 of his last 3 outings.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Minnesota Twins at Detroit Tigers odds, picks and predictions
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