The Minnesota Twins (67-73) and Chicago White Sox (73-67) meet Friday to commence a 3-game AL Central series. First pitch from Rate Field in Chicago, Illinois, is set for 7:40 p.m. ET. Let's analyze MLB odds around the Twins vs. White Sox odds and make our expert MLB picks and predictions for the best bets.
Season series: White Sox lead 6-4
The Twins lost 11-6 to the Detroit Tigers Wednesday after annihilating their opponent a combined 26-3 in the first 2 games of the series. They closed as a -120 favorite in the finale with the over (8.5) cashing. Minnesota, which sits third in the AL Central, has struggled over the past few weeks, going 4-8 over its last 12 games.
The White Sox, who lead the AL Central, lost 6-2 to the Houston Astros Thursday,
closing as a +130 moneyline underdog with the Under (8.5) hitting. They ended up dropping 3 of 4 games in that series. Chicago hasn't maintained much consistency over the last 3 weeks, going just 8-8 in its previous 16 games. It is 3 games ahead of the Cleveland Guardians in their race for the divisional crown.
Watch MLB on Fubo!
Twins at White Sox projected starters
RHP Zebby Matthews vs. RHP Erick Fedde
Matthews (9-8, 4.58 ERA) makes his 20th start. He has a 1.26 WHIP, 2.6 BB/9 and 7.5 K/9 in 112 innings.
- Last start: Win, 8 1/3 IP, 1 ER, 5 H, 0 BB, 5 K in a 5-1 home victory vs. White Sox Sunday
- Career vs. White Sox: 1-1, 3.24 ERA (25 IP, 9 ER), 1.08 WHIP, 7.2 K/9 in 4 starts
- 2026 road splits: 4-4, 6.38 ERA (55 IP, 39 ER), 1.42 WHIP, 13 HR< 17 BB, 58 K in 10 starts
Fedde (7-8, 4.16 ERA) makes his 14th start (30th appearance). He has a 1.37 WHIP, 3.3 BB/9 and 6.4 K/9 in 123 1/3 innings.
- Last start: Win, 5 IP, 2 ER, 3 H, 2 BB, 4 K in a 3-2 win at Twins Saturday
- Career vs. Twins: 4-0, 1.36 ERA (33 IP, 5 ER), 0.73 WHIP, 8.5 K/9 in 6 starts
- 2026 home splits: 2-2, 3.38 ERA (58 2/3 IP, 22 ER), 1.38 WHIP, 12 HR, 23 BB, 37 K in 14 appearances (4 starts)
Twins at White Sox odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:01 a.m. ET.
- Moneyline (ML): Twins +100 (bet $100 to win $100) | White Sox -120 (bet $120 to win $100)
- Run line (RL)/Against the spread (ATS): Twins -1.5 (+165) | White Sox +1.5 (-200)
- Over/Under (O/U): 9.5 (O: -102 | U: -118)
Slide into: BaseballHQ.com for your fantasy baseball news. For decades, BHQ has been helping players just like you win! BHQ offers full-season subscriptions. Sign up today!
Twins at White Sox picks and predictions
Prediction
White Sox 5, Twins 3
Moneyline
BET WHITE SOX (-120).
The pitching discrepancy is huge here. Matthews has a road ERA of 6.38 and hasn't performed well away from home, while Fedde has dominated the Twins. Chicago has won 4 of its last 6 home games as well.
Minnesota, while it was on fire offensively against Detroit, hasn't sustained that for much of the season. It has scored 4 runs or fewer in 4 of its last 8 games. The Twins are 1-7 in their last 8 away contests.
Run line/Against the spread
PASS.
Avoid this play. The Twins -1.5 (+160) are too risky to take as an ATS favorite here, while the White Sox +1.5 (-200) are far too risky as the underdog.
Over/Under
BET UNDER 9.5 (-118).
The Twins are trending toward the Over here, solely due to throttling the Tigers. They are still just 3-2 O/U in their last 5 games. Minnesota has allowed 2 runs or fewer in 3 of its last 4 games, so it has defended well.
For the White Sox, they are 1-5 O/U in their previous 6 outings. Chicago has scored a total of 14 runs in that span and have gone Under in Fedde's last 2 starts.
Betting odds calculator
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow SportsbookWire on Twitter/X and on Facebook.
This article originally appeared on Sportsbook Wire: Minnesota Twins at Chicago White Sox odds, picks and predictions
Our editors independently choose our recommendations. Some content is produced with paid support from a third party, however our editorial decisions remain independent. If you buy through our links, the USA TODAY Network may earn a commission. Prices and availability may change.
Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. Terms apply, see operator site for Terms and Conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER (NJ, OH), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800-9-WITH-IT (IN). Must be 21 or older to gamble. Sports betting and gambling are not legal in all locations. Be sure to comply with laws applicable where you reside. It is your sole responsibility to act in accordance with your local laws.
Gambling involves risk. Please only gamble with funds that you can comfortably afford to lose. While we do our utmost to offer good advice and information we cannot be held responsible for any loss that may be incurred as a result of gambling. We do our best to make sure all the information that we provide on this site is correct. However, from time to time mistakes will be made and we will not be held liable. Please check any stats or information if you are unsure how accurate they are. No guarantees are made with regards to results or financial gain. All forms of betting carry financial risk and it is up to the individual to make bets with or without the assistance of information provided on this site and we cannot be held responsible for any loss that may be incurred as a result of following the betting tips provided on this site. Past performances do not guarantee success in the future and betting odds fluctuate from one minute to the next. The material contained on this site is intended to inform, entertain and educate the reader and in no way represents an inducement to gamble legally or illegally or any sort of professional advice.
Prediction Markets: Certain prediction markets are event contracts regulated by the U.S. Commodity Futures Trading Commission (CFTC) or other applicable regulatory authorities and are legally distinct from traditional gambling and sports betting. Eligibility requirements to participate in prediction markets differ from those for sports betting and gambling — you may be required to be 18 or older (or such other age as the applicable platform requires) and to satisfy other eligibility criteria established by the relevant platform and governing law. Prediction market trading involves financial risk and may not be available in all jurisdictions. The legal and regulatory status of prediction markets varies by jurisdiction and by platform. It is your sole responsibility to confirm that participation is lawful where you reside and to comply with all applicable laws and platform terms.
