The Arizona Diamondbacks (71-63) and the San Francisco Giants (54-79) open a 4-game series Thursday at Oracle Park in San Francisco, California. First pitch is scheduled for 9:45 p.m. ET. Let's analyze MLB odds around the Diamondbacks vs. Giants odds and make our expert MLB picks and predictions for the best bets.
Season series: Diamondbacks lead 8-1
The Diamondbacks have dominated this season series, winning 8 of 9 meetings, but the Giants won 6-4 in the most recent matchup July 1 as slight underdogs (+110) in Arizona as the Over (9.5) cashed. The total has gone high at a 5-1-1 clip in the past 7 in the series.
Arizona (+104) won 2-0 in the series finale against the Chicago Cubs behind LHP Eduardo Rodriguez (Win, 7 IP, 0 ER, 2 H, 3 BB, 9 K), clinching
the series with 2 wins in 3 games. CF Jordan Lawlar went 2 for 3 with a solo homer for the Snakes.
The Diamondbacks are 5-2 in the past 7 games, while the Under is 3-1 in the previous 4 outings. The offense has managed just 3.0 runs per game (RPG) in the past 4 games, with the pitching allowing just 3.5 RPG.
The Giants lost 10-9 in the series finale Wednesday against the Cincinnati Reds, but they still won the series with 2 wins. The Giants are just 2-5 in the past 7 outings, however, while the Under is 5-3 across the previous 8 contests.
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Diamondbacks at Giants projected starters
RHP Jose Cabrera vs. RHP Landen Roupp
Cabrera (0-2, 5.60 ERA) makes his fifth-career MLB start. The rookie has a 1.53 WHIP, 3.6 BB/9, 6.1 K/9 in 17 2/3 innings.
- Last start: Loss, 4 1/3 IP, 4 ER, 4 H, 2 BB, 2 K in 10-4 loss at San Diego Padres July 8
- 2026 road splits (2 starts): 0-2, 7.71 ERA (9 1/3 IP, 8 ER), 2 HR, 4 BB, 6 K
- Has never faced Giants
Roupp (7-13, 4.34 ERA) makes his 26th start. He has a 1.31 WHIP, 4.3 BB/9, 8.7 K/9 in 134 2/3 innings.
- Last start: Loss, 5 1/3 IP, 3 ER (4 R), 5 H, 4 BB, 2 K in 5-2 loss at Cleveland Guardians last Thursday
- 2026 home splits (11 starts): 3-7, 4.22 ERA (59 2/3 IP, 28 ER), 1.21 WHIP, 4 HR, 28 BB, 60 K
- Career vs. Diamondbacks (4 starts, 6 appearances): 0-2, 5.40 ERA (23 1/3 IP, 14 ER), 1.84 WHIP, 9.3 K/9
Diamondbacks at Giants odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:47 p.m. ET.
- Moneyline (ML): Diamondbacks -110 (bet $110 to win $100) | Giants -110 (bet $110 to win $100)
- Run line (RL)/Against the spread (ATS): Diamondbacks -1.5 (+155) | Giants +1.5 (-190)
- Over/Under (O/U): 8 (O: -105 | U: -115)
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Diamondbacks at Giants picks and predictions
Prediction
Giants 6, Diamondbacks 5
Moneyline
The GIANTS (-110) are worth a look at home in this series opener behind Roupp. It's not so much that the San Francisco right-handed starter can be trusted, but Cabrera has been so shaky in his previous outings.
Run line/Against the spread
If are super conservative, and can't bring yourself to take the home team straight up, GIANTS +1.5 (-190) is just too much. When it was at -180, my personal limit, it was fine. If you need some insurance, and you use San Francisco in a multi-leg parlay, go for it.
Over/Under
The OVER 8 (-105) is the best play in the series opener with Cabrera and Roupp hemorrhaging runs in their starts this season. Expect to see plenty of offense in this game, and it's a rather low line considering their giving ways.
OVER 4.5 - FIRST 5 INNINGS (-105) is also a strong play, as these 2 starters should be hit hard early.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Arizona Diamondbacks at San Francisco Giants odds, picks and predictions
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