The San Diego Padres (81-68) and Colorado Rockies (55-94) meet Monday in Denver, Colorado, to begin a 4-game series. First pitch at Coors Field is set for 8:40 p.m. ET. Let's analyze MLB odds around the Padres vs. Rockies odds and make our expert MLB picks and predictions for the best bets.
Season series: Padres lead 8-1
The Padres have been on a much-needed tear, sweeping the San Francisco Giants and the Washington Nationals across their last 2 series. They are coming off a 6-4 road win over the Giants Sunday, closing as a -143 favorite with the Over (7.5) cashing. San Diego sits in the final NL Wild Card spot and is 2 1/2 games ahead of its closest contender, the Arizona Diamondbacks.
The Rockies, who were eliminated from playoff contention quite
a while ago, have lost 7 straight games. They lost 8-1 to the Detroit Tigers Sunday, closing as a +157 moneyline underdog with the total (9) pushing. Colorado's defense has been atrocious as of late, allowing at least 5 runs in 10 straight contests. It is 3-8 in September.
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Padres at Rockies projected starters
RHP Casey Mize vs. RHP Tomoyuki Sugano
Mize (5-9, 3.70 ERA) makes his 24th start. He has a 1.11 WHIP, 2.2 BB/9 and 8.1 K/9 in 119 1/3 innings.
- Last start: No-decision, 5 2/3 IP, 3 ER, 4 H, 1 BB, 7 K in a 5-4 home win vs. Washington Nationals Tuesday
- Career vs. Rockies: 1-0, 4.22 ERA (10 2/3 IP, 5 ER), 0.84 WHIP, 12.7 K/9 in 2 starts
- 2026 road splits: 3-6, 4.25 ERA (59 1/3 IP, 28 ER), 1.25 WHIP, 8.2 K/9 in 12 starts
Sugano (12-9, 5.30 ERA) makes his 27th start. He has a 1.34 WHIP, 2.2 BB/9 and 5.5 K/9 in 137 2/3 innings.
- Last start: Loss, 6 IP, 5 ER, 4 H, 3 BB, 5 K in a 6-1 road loss vs. New York Yankees Wednesday
- Career vs. Padres: 1-0, 2.31 ERA (11 2/3 IP, 3 ER), 0.86 WHIP, 5.4 K/9 in 2 starts
- 2026 home splits: 7-5, 4.96 ERA (69 IP, 38 ER), 1.32 WHIP, 5.1 K/9 in 13 starts
Padres at Rockies odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:48 a.m. ET.
- Moneyline (ML): Padres -200 (bet $200 to win $100) | Rockies +165 (bet $100 to win $165)
- Run line (RL)/Against the spread (ATS): Padres -1.5 (-135) | Rockies +1.5 (+110)
- Over/Under (O/U): 11 (O: -102 | U: -118)
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Padres at Rockies picks and predictions
Prediction
Padres 9, Rockies 3
Moneyline
PASS.
Avoid this play. The Padres (-200) have a playoff race to continue vying for and should win outright. They are a bit too expensive sive to consider here, though.
Run line/Against the spread
BET PADRES -1.5 (135).
The Rockies just haven't been competitive in the past few weeks. They've dropped 7 straight, with each of those coming by multiple runs and 5 of those contests having a margin of 4 runs or greater. Colorado is just 1-4 ATS in Sugano's last 5 starts as well.
The Padres are in win-now mode, and they've been surging. The key part of their win streak has been the offensive consistency. They've scored at least 5 runs in 5 straight games, and against Sugano, they should be able to keep winning by a substantial margin. San Diego has won 3 of its last 4 games by more than 1 run. If you're feeling adventuresome, consider Padres -2.5 (+110), or even -3.5 (+170).
Over/Under
BET OVER 11 (-102).
Both sides are trending toward the Over. The Rockies are 6-1-2 O/U in their previous 9 outings and have allowed double-digit runs in 3 of those.
The Padres have been on a tear offensively and have gone Over in 5 straight performances. They have scored at least 5 runs in each of those while allowing at least 4 runs in 4 of them. San Diego has topped the total in Mize's last 4 starts.
Best prop bet
BET OVER CASEY MIZE 4.5 STRIKEOUTS (+130).
The Rockies rank seventh in the majors for the most strikeouts. With Mize's coming off a strong performance against the Nationals, throwing 7 Ks, expect another good outing from the Padres starts and take his Over here.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: San Diego Padres at Colorado Rockies odds, picks and predictions
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