The Iowa State Cyclones (3-3, 1-2 Big 12) and the Arizona Wildcats (5-1, 2-1) meet Saturday at Casino Del Sol Stadium in Tucson, Arizona. Kickoff is scheduled for 7:30 p.m. ET (ESPN2). Let's analyze college football odds around the Iowa State vs. Arizona odds and make our expert college football picks and predictions for the best bets.
Arizona leads all-time series 4-2-1; Iowa State won the first meeting as Big 12 members last season, a 39-14 victory in Ames. Iowa State's previous win in the series was in 1958 in Tucson.
The Cyclones suffered a 24-10 loss at BYU on Oct. 9 in their most recent game, failing to cover as an 11.5-point underdog as the Under (46.5) cashed. Iowa State has alternated losses and wins in each of its 6 games to date, with
the Over going 3-1 in the past 4 contests.
The Wildcats, unranked in the Coaches' Poll, but No. 25 in The Associated Press Top 25, bounced West Virginia 52-31 last time out on Oct. 10 as a 3.5-point favorite as the Over (61.5) cashed. Arizona QB Noah Fifita threw for 341 yards, 3 TDs and 1 INT in last week's win over the Mountaineers, with WR Isaiah Mizell hauling in 6 receptions for 183 yards and 2 TDs. Arizona has won 4 in a row, while covering the past 2 games after going 0-4 against the spread (ATS) in the first 4 outings. The Over is 3-1 in the past 4 games, as Arizona has scored 34+ in each of those outings.
– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports
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Iowa State at Arizona odds
Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:15 a.m. ET.
- Moneyline (ML): Iowa State +300 (bet $100 to win $300) | Arizona -375 (bet $375 to win $100)
- Against the spread: Iowa State +11 (-110) | Arizona -11 (-108)
- Over/Under (O/U): 51.5 (O: -105 | U: -112)
Iowa State at Arizona picks and predictions
Prediction
Arizona 27, Iowa State 13
Moneyline
Arizona (-375) will set you back nearly 4 times your potential return, and that's way too much risk for not enough reward. You would need to risk $100 to win less than $26, and there is never a reason to risk so much for so little.
PASS.
Against the spread
ARIZONA -11 (-108) is rolling right along, and worth playing in this conference battle. The Wildcats have won 4 in a row, piling up at least 34 points in each of the victories.
Iowa State has been much more erratic, scoring 17 or fewer points in 3 of its past 5 outings and scoring at least 38 in the other 3 games (and all of those at home). On the road, the Cyclones are 0-2 SU/1-1 ATS, getting outscored 40-23 in those games.
Over/Under
UNDER 51.5 (-112) might be the best play on the board. Yes, Arizona's offense has been on fire lately, but Iowa State seems to rally around its defense on the road. Unfortunately, the Cyclones' offense is unable to generate much away from home. That's great news for the Under, though. The Under is 2-1 in 3 home games for Arizona, too.
Best prop bet
ARIZONA RB KEDRICK REESCANO - OVER 55.5 RUSHING YARDS (-114 on FanDuel)
Reescano is Arizona's best bet in the backfield, and he'll be operating against an Iowa State rush defense which allows 153.8 yards per game on the ground, 91st in the nation. If you want a little more of a certainty -- he has scored touchdowns in each of the past 2 games -- as an Anytime TD Scorer (-160 on FanDuel), he isn't priced out of line.
Betting odds calculator
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow Daniel Dobish on X at @danieledobish. Follow SportsbookWire on X at SportsBookWire and on Facebook.
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This article originally appeared on Sportsbook Wire: Iowa State Cyclones at Arizona Wildcats odds, picks and predictions
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