The Green Bay Packers (4-2) and Detroit Lions (3-2) square off Sunday at Ford Field in Detroit, Michigan, for a NFC North battle. Kickoff is scheduled for 4:25 p.m. ET (FOX). Let's analyze NFL odds around the Packers vs. Lions odds and make our expert NFL picks and predictions for the best bets.
Whoever takes this divisional tilt between the Packers and Lions will stay alive in the always tight NFC North. With the Chicago Bears (5-2) winning Thursday and the Minnesota Vikings still undefeated (5-0), the loser won't be out of the postseason picture, but it will be a tough climb up the NFC North.
Of the two, the Packers head to Ford Field as the hotter team. Winners of 3 straight, Green Bay's defense made the Dallas Cowboys offense-heavy team look
lifeless in Week 6. It was QB Jordan Love's only game in 2026 without 2+ TD passes, but he guided the Packers well enough going 23 for 41 with 276 yards with a TD and INT. It's unclear if the Pack will have RB Josh Jacobs, reinstated by the NFL earlier this week, on the field. However, Love did hint at his return.
Detroit is fresh off their bye in Week 6. Prior to that, the Lions have have alternated wins and losses each week this season. On offense, Detroit has been steady throughout the year with WR Amon-Ra St. Brown and QB Jared Goff, who has 12 TDs and no INTs. Defensively, it's a completely different story. Detroit ranks dead last in total defense (404.4 yards per game) and pass defense (297.4 YPG).
The Packers swept the divisional series last season. Against the spread, Green Bay and Detroit are 3-3 and 2-3, respectively, in 2026. The Packers have hit the Over just twice while the Lions have hit the Over every game .
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Packers at Lions odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 8:33 p.m. ET.
- Moneyline (ML): Packers +155 (bet $100 to win $155) | Lions -190 (bet $190 to win $100)
- Against the spread (ATS): Packers +3.5 (-108) | Lions -3.5 (-110)
- Over/Under (O/U): 54.5 (O: -110 | U: -110)
Packers at Lions key injuries
Packers
- OG Aaron Banks (knee/ toe) questionable
- LB Zaire Franklin (shin) out
- WR Bo Melton (back) questionable
- DT Jordan Riley (Achilles) questionable
- CB Benjamin St.-Juste (hamstring) questionable
Lions
- DB Brian Branch (Achilles) questionable
- OL Cade Mays (wrist) questionable
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Jets at Patriots picks and predictions
Prediction
Packers 31, Lions 27
Moneyline
BET PACKERS (+155).
The Lions have the luxury of coming out of their bye to face the Packers, but divisional matchups will be tight regardless of the circumstance in the NFL. Feelings should lie heavier on the fact Green Bay has heated up in recent weeks. Plus, Love has thrown for at least 276 yards over the past 2 games of Green Bay's winning streak. Focus on that considering how awful Detroit's defense has been against the pass.
Against the spread
BET PACKERS +3.5 (110).
If you want a few points insurance, go with the Packers.
Over/Under
BET OVER 54.5 (-110).
While the Packers are hot, despite their record, the Lions continue to cash in on the Over. Considering this one is in Detroit, expect the Lions to put up plenty of points to push this above a big number.
Best prop bet
Bet Packers QB JORDAN LOVE OVER 281.5 PASS YARDS (-114).
Don't overthink this one. The Lions give up both points and yards to quarterbacks and Love and the Packers have been heating up.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Green Bay Packers at Detroit Lions odds, picks and predictions
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