The San Francisco Giants (57-81) and the Pittsburgh Pirates (67-71) open a 3-game series Tuesday at PNC Park in Pittsburgh, Pennsylvania. First pitch is scheduled for 6:40 p.m. ET. Let's analyze MLB odds around the Giants vs. Pirates odds and make our expert MLB picks and predictions for the best bets.
Season series: Giants lead 2-1
The Giants played a make-up game Monday in Atlanta, winning 7-3 as heavy underdogs (+180) as the Over (9) cashed. DH Rafael Devers went 1 for 3 with a solo home run, his 30th homer of the season, while adding 2 runs and 2 walks. The Giants are a respectable 5-3 across the past 8 outings, while the Over is 3-1 in the past 4 games. The offense has scored 6 or more runs in 5 of the past 6 games, averaging 6.0 runs per
game (RPG).
The Pirates (-120) won 5-4 in the series finale Sunday at the St. Louis Cardinals, clinching the series win with 2 wins in 3 games. SS Jared Triolo and RF Esmerlyn Valdez each swatted homers in Sunday's victory. The Over (7.5) cashed Sunday, halting a 10-game Under run. The Bucs have won 4 of the past 6 games.
The Giants are 12-10 against NL Central teams, but they're just 24-45 on the road. The Pirates are 11-16 vs. NL West clubs, while going 34-32 at home.
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Giants at Pirates projected starters
RHP Logan Webb vs. RHP Paul Skenes
Webb (8-8, 3.72 ERA) makes his 25th start. He has a 1.10 WHIP, 2.2 BB/9, 7.2 K/9 in 147 2/3 innings.
- Last start: No-decision, 6 IP, 2 ER, 5 H, 1 HR, 1 BB, 6 K in 10-9 home loss vs. Cincinnati Reds Wednesday
- 2026 road splits (11 starts): 4-4, 4.16 ERA (62 2/3 IP, 29 ER), 1.24 WHIP, 8 HR, 23 BB, 54 K
- Career vs. Pirates (5 starts): 2-1, 2.37 ERA (30 1/3 IP, 8 ER), 1.25 WHIP, 11.9 K/9
Skenes (9-11, 3.79 ERA) makes his 28th start. He has a 1.12 WHIP, 2.5 BB/9, 10.9 K/9 in 145 innings.
- Last start: No-decision, 6 IP, 0 ER, 3 H, 0 BB, 4 K in 1-0 win at San Diego Padres last Tuesday
- 2026 home splits (14 starts): 5-5, 3.59 ERA (77 2/3 IP, 31 ER), 1.06 WHIP, 6 HR, 20 BB, 104 K
- Career vs. Giants (1 start): No-decision, 6 IP, 1 ER, 6 H, 1 BB, 3 K in 7-6 home loss May 23, 2024
Giants at Pirates odds
Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:08 a.m. ET.
- Moneyline (ML): Giants +138 (bet $100 to win $138) | Pirates -164 (bet $164 to win $100)
- Run line (RL)/Against the spread (ATS): Giants +1.5 (-178) | Pirates -1.5 (+146)
- Over/Under (O/U): 7.5 (O: +100 | U: -122)
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Giants at Pirates picks and predictions
Prediction
Giants 4, Pirates 3
Moneyline
The GIANTS (+138) are worth a look as road underdogs in the series opener.
Skenes hasn't pitched consistently this season, and Webb has nearly identical overall numbers. Back San Francisco, which is a better value on the road at plus-money.
Run line/Against the spread
The GIANTS +1.5 (-178) are a little pricey if you're on the conservative side, and you need a little insurance against Skenes. Again, he hasn't been nearly as automatic as we saw in his first 2 MLB seasons, and the first 2 months of this season. Skenes has been very medicore, making San Francisco a tremendous value.
Over/Under
UNDER 7.5 (-122) is the lean, but go with a half-unit play at best.
Remember, the total has gone low in 10 of the past 11 games for the Bucs, and the Under is 4-0 in the past 4 outings with Skenes on the bump. The offense dries up when the star pitcher is on the hill, and Pittsburgh has posted 7 total runs of support in the 4-game span, or just 1.8 RPG.
Be careful, though, as the Over is 3-0 in Webb's past 3 outings, and the offense has posted 6+ runs in 5 of the past 6 contests.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: San Francisco Giants at Pittsburgh Pirates odds, picks and predictions
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