The Houston Texans (0-2) and the Indianapolis Colts (0-2) meet Sunday for a Week 3 matchup at Lucas Oil Stadium in Indianapolis, Indiana. Kickoff is scheduled for 1 p.m. ET (CBS). Let's analyze NFL odds around the Texans vs. Colts odds and make our expert NFL picks and predictions for the best bets.
The Texans have won 5 consecutive meetings and are 6-1-1 straight up (SU) in the past 8 in the series since Sept. 11, 2022. These division rivals have cashed the Under in 6 of the past 10 in the series, with the Under holding a 3-2 edge in the past 5 meetings in Indianapolis. The Colts are 3-1 against the spread (ATS) in the past 4 meetings while the Texans are 3-1 ATS in the past 4 trips to Indy. Last season, Houston posted a 20-16 win as a 3-point
underdog on Nov. 30, as the Under (44.5) cashed.
Houston is playing its first game on the road. It lost the first 2 games at home, falling 36-31 to Buffalo as a 1.5-point underdog, and 20-6 last Sunday against Cincinnati as a 2.5-point favorite. The Over-Under has split in those 2 games.
Indianapolis was blasted 41-23 in Week 1 at home as a 2.5-point underdog against Baltimore as the Over (47.5) cashed. In Week 2, the Colts were competitive, but fell 33-30 in overtime to the Chiefs in Kansas City as a 5.5-point underdog. The Over has connected in both outings.
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Texans at Colts odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 5:36 p.m. ET.
- Moneyline (ML): Texans -125 (bet $125 to win $100) | Colts +105 (bet $100 to win $105)
- Against the spread (ATS): Texans -2 (-108) | Colts +2 (-110)
- Over/Under (O/U): 42.5 (O: -110 | U: -108)
Texans at Colts injuries
Texans
- DE Jadeveon Clowney (knee) out
- WR Nico Collins (hamstring) out
- LB Jacob Hummel (groin) out
- G Ed Ingram (groin) out
- S M.J. Stewart (knee) out
- T Trent Brown (knee, wrist) questionable
Colts
- WR Ashton Dulin (ankle) out
- WR Alec Pierce (heel) out
- CB Charvarius Ward (groin) questionable
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Texans at Colts picks and predictions
Prediction
Colts 26, Texans 23
Moneyline
Yes, they have lost 5 in a row in this series, but COLTS (+105) are the play at home.
Colts RB Jonathan Taylor is about to make things worse for the Texans. Houston has allowed 171 rushing yards in the first 2 games, and 3.9 yards per attempt. Those numbers are not terrible, but this will be Houston's first road game and the defense won't perform nearly as well.
Against the spread
There is absolutely no sense backing Colts +2 (-110), unless you're absolutely convinced Houston will win, but only by 1 point. If you like Indy, don't pay up for minimal insurance. Just take Indy straight up.
PASS.
Over/Under
OVER 42.5 (-110) is the play in this AFC South battle.
The Over is 2-0 for Indianapolis through 2 games as the Colts have allowed 37.0 PPG, including 41 at home in Week 1 against the Ravens. The Colts have averaged a respectable 26.5 PPG on offense, too. Defensively, the Texans have allowed 28.0 PPG, so this will be anything but a defensive slog.
Best Prop to Bet
Colts RB Jonathan Taylor - ANYTIME TD (-150) is a little pricey for an Anytime TD, but he is a good bet to sniff out the end zone. He has scored twice on the ground in each of his first 2 games, and he has 4 rushing TDs in his past 3 home games. Of course, Houston is the last team to hold him without a touchdown at Lucas Oil Stadium on Nov. 30, 2025, but don't let that dissuade you.
Betting odds calculator
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow Daniel Dobish on X at @danieledobish. Follow SportsbookWire on X at SportsBookWire and on Facebook.
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This article originally appeared on Sportsbook Wire: Houston Texans at Indianapolis Colts odds, picks and predictions
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