The Houston Astros (73-71) and Philadelphia Phillies (81-63) meet Tuesday to commence a 3-game series. First pitch from Citizens Bank Park in Philadelphia, Pennsylvania, is set for 6:40 p.m. ET. Let's analyze MLB odds around the Astros vs. Phillies odds and make our expert MLB picks and predictions for the best bets.
2025 season series: Astos won 3-0
The Astros lost to the Arizona Diamondbacks 3-2 Sunday as a -121 moneyline favorite as the Under (8) hit with ease. Houston dropped the final 2 games in that series, but is still a solid 5-3 over its last 8 games. The Astros sit atop the NL West, 2 games ahead of the Texas Rangers.
The Phillies are second in the NL East, 4 games behind the Atlanta Braves, but they are No. 1 in the NL Wild Card. Philadelphia
beat the Braves 1-0 Monday, trading off winning and losing in that 4-game series. It has won 8 of its last 11 overall and 9 of its last 11 at home.
Watch MLB on Fubo!
Astros at Phillies projected starters
RHP Hayden Wesneski vs. RHP Andrew Painter
Wesneski (4-1, 3.18 ERA) makes his eighth start. He has a 1.06 WHIP, 3.2 BB/9 and 7.5 K/9 in 39 2/3 innings.
- Last start: No-decision, 7 IP, 0 ER, 1 H, 2 BB, 5 K in a 2-0 home victory vs. Chicago White Sox Wednesday
- Career vs. Phillies: 1-1, 4.96 ERA (16 1/3 IP, 9 ER), 1.29 WHIP, 9.9 K/9 in 2 starts (4 appearances)
- 2026 road splits: 2-0, 3.57 ERA (17 2/3 IP, 7 ER), 1.19 WHIP, 2 HR, 6 BB, 14 K in 3 starts
Painter (3-8, 5.55 ERA) makes his 20th career start (22nd appearance). The 23-year-old rookie has a 1.37 WHIP, 3.2 BB/9 and 7.8 K/9 in 105 1/3 innings.
- Last start: No-decision, 7 IP, 0 ER, 2 H, 0 BB, 6 K in 1-0 loss at Arizona Diamondbacks Wednesday
- First time facing Astros
- 2026 home splits: 2-5, 5.81 ERA (48 IP, 31 ER), 1.35 WHIP, 8 HR, 15 BB, 46 K in 9 starts (10 appearances)
Astros at Phillies odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:01 a.m. ET.
- Moneyline (ML): Astros +125 (bet $100 to win $125) | Phillies -150 (bet $150 to win $100)
- Run line (RL)/Against the spread (ATS): Astros +1.5 (-165) | Phillies -1.5 (+135)
- Over/Under (O/U): 8.5 (O: -118 | U: -102)
Slide into: BaseballHQ.com for your fantasy baseball news. For decades, BHQ has been helping players just like you win! BHQ offers full-season subscriptions. Sign up today!
Astros at Phillies picks and predictions
Prediction
Astros 4, Phillies 3
Moneyline
BET ASTROS (+125).
The Astros have dominated with Wesneski on the mound. They've gone 6-1 in his 7 starts, and he has allowed just 1 ER in his last 17 IP. Houston has won 2 of 3 games in its last 3 road series, with one of those being against the 81-win New York Yankees.
The Phillies have been hot over the last few weeks, but more recently, their offense has struggled. They've scored a total of 11 runs across their last 5 games and were held to 2 runs or fewer in 3 of those contests. Philadelphia is 2-3 in its last 5 outings.
Run line/Against the spread
PASS.
Avoid this play. The Astros +1.5 (-165) are too expensive to consider here as an underdog, while the Phillies -1.5 (+135) are a bit risky as the favorite, especially given Painter's inconsistency this season.
Over/Under
BET UNDER 8.5 (-102).
Neither side is really surging offensively, and that's concerning here.
The Phillies, who are 65-73-6 O/U, have gone 1-3-1 O/U in their last 5 games. They've allowed 3 runs or fewer in 9 of their last 11 games. The Astros have ended south of the total in 6 straight contests and in Wesneski's last 3 starts. They've scored a total of 8 runs in their last 3 games.
Betting odds calculator
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow SportsbookWire on Twitter/X and on Facebook.
This article originally appeared on Sportsbook Wire: Houston Astros at Philadelphia Phillies odds, picks and predictions
Our editors independently choose our recommendations. Some content is produced with paid support from a third party, however our editorial decisions remain independent. If you buy through our links, the USA TODAY Network may earn a commission. Prices and availability may change.
Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. Terms apply, see operator site for Terms and Conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER (NJ, OH), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800-9-WITH-IT (IN). Must be 21 or older to gamble. Sports betting and gambling are not legal in all locations. Be sure to comply with laws applicable where you reside. It is your sole responsibility to act in accordance with your local laws.
Gambling involves risk. Please only gamble with funds that you can comfortably afford to lose. While we do our utmost to offer good advice and information we cannot be held responsible for any loss that may be incurred as a result of gambling. We do our best to make sure all the information that we provide on this site is correct. However, from time to time mistakes will be made and we will not be held liable. Please check any stats or information if you are unsure how accurate they are. No guarantees are made with regards to results or financial gain. All forms of betting carry financial risk and it is up to the individual to make bets with or without the assistance of information provided on this site and we cannot be held responsible for any loss that may be incurred as a result of following the betting tips provided on this site. Past performances do not guarantee success in the future and betting odds fluctuate from one minute to the next. The material contained on this site is intended to inform, entertain and educate the reader and in no way represents an inducement to gamble legally or illegally or any sort of professional advice.
Prediction Markets: Certain prediction markets are event contracts regulated by the U.S. Commodity Futures Trading Commission (CFTC) or other applicable regulatory authorities and are legally distinct from traditional gambling and sports betting. Eligibility requirements to participate in prediction markets differ from those for sports betting and gambling — you may be required to be 18 or older (or such other age as the applicable platform requires) and to satisfy other eligibility criteria established by the relevant platform and governing law. Prediction market trading involves financial risk and may not be available in all jurisdictions. The legal and regulatory status of prediction markets varies by jurisdiction and by platform. It is your sole responsibility to confirm that participation is lawful where you reside and to comply with all applicable laws and platform terms.
