The Denver Broncos (4-2) and Arizona Cardinals (2-4) meet in Week 7 on Sunday in Glendale, Arizona. Kickoff at State Farm Stadium is at 4:05 p.m. ET (CBS). Let's analyze NFL odds around the Broncos vs. Cardinals odds and make our expert NFL picks and predictions for the best bets.
The Broncos come into Week 7 with 2 consecutive wins. They are coming off a mini-bye, as they beat the Seattle Seahawks 17-14 in overtime last Thursday as 2.5-point road underdogs with the Under (40.5) cashing. The defense intercepted QB Sam Darnold twice, and despite only passing for 107 yards, Broncos QB Bo Nix led his fourth game-winning drive of the season when K Wil Lutz hit a 53-yard field goal in overtime.
The Cardinals snapped a 4-game losing streak last Sunday,
beating the LA Rams 18-16 on the road as 13.5-point underdogs with the Under (51.5) cashing. K Chad Ryland scored all the points, making all 6 of his field goals, including a 43-yarder as time expired. He won NFC Special Teams Player of the Week. After allowing over 30 points in 4 consecutive games, the defense had its best performance of the season.
The Broncos lead the Cardinals all-time 10-1-1. They last played in 2022, a 24-15 Broncos win in Denver as 2.5-point underdogs with the Over (36.5) cashing.
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Broncos at Cardinals odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 3 p.m. ET.
- Moneyline (ML): Broncos -225 (bet $225 to win $100) | Cardinals +185 (bet $100 to win $185)
- Against the spread (ATS): Broncos -4.5 (-108) | Cardinals +4.5 (-110)
- Over/Under (O/U): 43 (O: -110 | U: -108)
Broncos at Cardinals key injuries
Broncos
- RB Tyler Badie (thumb) out
- RB Jonah Coleman (ankle) questionable
- OLB Jonah Elliss (ankle) out
- S Talanoa Hufanga (ankle) out
- CB Pat Surtain II (ankle) questionable
Cardinals
- S Budda Baker (groin) questionable
- OL Jon Gaines (knee, ankle) out
- RB Jeremiyah Love (ankle) out
- CB Max Melton (knee) questionable
- DL Walter Nolen (ankle) out
- DL Darius Robinson (back) questionable
- S Andrew Wingard (knee) out
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Broncos at Cardinals picks and predictions
Prediction
Broncos 24, Cardinals 20
Moneyline
The Cardinals have not won a home game since Week 2 of 2025. They haven't beaten the Broncos since 2010, their only all-time win against them. They had their best defensive performance of the year last Sunday, but they will be missing Nolen up front and perhaps Melton on the back end. And while Denver's offense has struggled this season (31st in yards), Nix comes up with enough good play at the end of games.
Cardinals QB Jacoby Brissett is 3-15 as a starter and 1-for-8 in game-winning scenarios at the end of games.
The Broncos win, but the spread gives you better value.
PASS.
Against the spread
Now, here is where two less-than-productive offenses come into play. This will come down to a late score or needing a late score.
Two of the Broncos' wins are by 4 or fewer points.
BET CARDINALS +4.5 (-110)
Over/Under
The total has been at least 60 in 3 of the Cardinals' last 4 games. However, the Under has cashed in 5 of the Broncos' 6 games this season.
Arizona's defense hasn't proven it can play well in consecutive games.
BET OVER 43 (-110).
Best prop bet
Cardinals QB Jacoby Brissett OVER 0.5 INTERCEPTIONS (-105)
Brissett has been picked off in 4 of 6 games this season, including the last 3 in a row. He has thrown 5 picks in the last 3 games.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Denver Broncos at Arizona Cardinals odds, picks and predictions
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