The Carolina Panthers (3-5) and the New Orleans Saints (3-5) meet Sunday for a Week 10 game at the Caesars Superdome in New Orleans, Louisiana. Kickoff is scheduled for 1 p.m. ET (FOX). Let's analyze NFL odds around the Panthers vs. Saints odds and make our expert NFL picks and predictions for the best bets.
Last season, the Saints swept the 2 regular-season meetings against the Panthers in this NFC South Division rivalry. New Orleans won 20-17 at home as a 2.5-point underdog on Dec. 14, 2025, as the Under (41.5) cashed, while the Saints won 17-7 in Charlotte on Nov. 9, 2025, as a 5.5-point underdog with the Under (38.5) also cashing. New Orleans has won 5 of the past 6 meetings, while going 4-1-1 against the spread (ATS) in the span. The Under is 8-2
in the previous 10 in the series.
Carolina suffered a 26-21 loss at home to the Denver Broncos as a 3.5-point underdog with the Over (44.5) cashing. QB Bryce Young threw for 276 yards, 3 TDs and 1 INT in the losing effort, while TE Darren Waller resurfaced with 8 catches, 90 yards and a TD. The Panthers have dropped 3 in a row, though, while also going 0-3 ATS in the span. The Over improved to 4-0 at home for Carolina, but the Under is 4-0 on the road.
New Orleans outlasted the Cleveland Browns 23-22, but it failed to cover as a 5.5-point favorite as the Over (43.5) cashed. The Saints led 23-16 in overtime when a Cleveland touchdown made it 23-22. The Browns elected to go for 2, but failed, as the Saints held on for the victory. RB rushed for 72 yards and a TD, while WR Chris Olave led the way with 98 receiving yards.
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Panthers at Saints odds
Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 10:45 p.m. ET.
- Moneyline (ML): Panthers +110 (bet $100 to $110) | Saints -135 (bet $135 to win $100)
- Against the spread (ATS): Panthers +2 (-108) | Saints -2 (-110)
- Over/Under (O/U): 49 (O: -108 | U: -110)
Panthers at Saints injuries
Panthers
- RB Jonathon Brooks (groin) doubtful
- OL Brady Christensen (hamstring) questionable
- CB Mike Jackson (groin) doubtful
- CB Will Lee III (hamstring) questionable
- WR Xavier Legette (knee) questionable
- LB Bobby Okereke (foot) out
- LB Jaelan Phillips (hamstring) questionable
Saints
- RB CJ Donaldson (shoulder) out
- CB Martin Emerson (shin) questionable
- RB Travis Etienne (hamstring) questionable
- OT Taliese Fuaga (knee) out
- C Erik McCoy (biceps) out
- DT Christen Miller (knee) out
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Panthers at Saints picks and predictions
Prediction
Saints 25, Panthers 22
Moneyline
The Saints (-135) are slight favorites, and there is no reason to pay up for little advantage, rather than just laying the little bit of points. Unless you're absolutely positive New Orleans will win by just 1 point, this play makes no sense.
AVOID.
THURSDAY NIGHT FOOTBALL: Best prop bets
Against the spread
The SAINTS -2 (-110) looks to build upon last week's thrilling OT win over the Browns. New Orleans has been a thorn in the side of Carolina for many years, and it has dominated this series with 5 wins in the past 6 installments, including a sweep of the eventual NFC South champion Panthers last season.
There is little reason to get away from the Saints, as they're playing with a little bit of steam, especially in the raucous dome down in New Orleans.
Over/Under
UNDER 49 (-110) is the lean but go with a half-unit play at most.
A total nearing 50 is an awfully high number in a Carolina game. And, it is a high total in this series. Generally, these games see few points, with the Under cashing in both meetings in 2025, and 8 of the past 10 in the series.
Yes, the Under has cashed in all 4 games for the Panthers on the road this season, as well, including a Week 2 divisional win in Atlanta.
Best prop bet
SAINTS WR CHRIS OLAVE ANYTIME TOUCHDOWN (+135).
Olave at plus money is a strong play. He had a touchdown in each against the Panthers last season, and he has scored in 4 of the past 7 meetings against Carolina.
Betting odds calculator
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow Daniel Dobish on X at @danieledobish. Follow SportsbookWire on X at SportsBookWire and on Facebook.
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This article originally appeared on Sportsbook Wire: Carolina Panthers at New Orleans Saints odds, picks and predictions
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