As previously declared earlier in the week, the Colts will be without 3 starters:
- Wide Receiver Alec Pierce
- Right Guard Matt Goncalves
- Cornerback Kenny Moore II
Depth players such as Eric Johnson II, Luke Tenuta, Will Mallory, and Riley Leonard (who can be activated mid-game incase of injury to QB1-2 Daniel Jones and Anthony Richardson) are also inactive. This is the first time Eric Johnson II is on the inactive list, as the Colts are opting to have 2nd Round Defensive End JT Tuimoloau suit up for the 2nd time this season
after he made his debut in Week 2 with starter Laiatu Latu out.
For the Rams, all 4 of their Questionable players are active:
- Starting Wide Receiver Davante Adams
- Starting Right Tackle Rob Havenstein
- Starting Tight End Tyler Higbee
- Tight End 2 Colby Parkinson
Adams, Havenstein, and Higbee were all dealing with leg injuries (hamstring, ankle, and hip respectively) throughout the week, while Parkinson was managing a shoulder injury.
The Rams inactives are all depth players, with 2nd Round rookie Tight End Terrance Ferguson back on the inactive list for the 2nd straight week.