The Arizona Cardinals need a win.
The Arizona Cardinals are playing with a lot of backups, specifically in the backfield, and need them to play better than they have been. Or at least smarter.
For the Cardinals, this game will help them stay competitive, but a loss could be the beginning of the end of the 2025 NFL season.
No big deal, Jacoby Brissett has got this.
Week 6: Arizona Cardinals (2-3) at Indianapolis Colts (4-1)
Date: Sunday, October 12, 2025 Time: 10:00 a.m. AT Location: Lucas Oil Stadium — Indianapolis, IN National TV: Fox (Channel 10 locally) National online
streaming: NFL+, FoxSports Streaming TV announcers: Kevin Kugler (play-by-play) Daryl Johnston (analyst) Allison Williams (sideline) Radio: Arizona Sports 98.7 FM Radio announcers: Dave Pasch (play-by-play), A.Q. Shipley (analyst) and Paul Calvisi (sideline) Spanish Radio: Fuego Radio 106.7 FM Spanish Radio announcers: Luis Hernandez (play-by-play) and Irving Villanueva (analyst) Betting line: Cardinals +7.5 per FanDuel Sportsbook
