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WEEK 4 202 5, Sunday, September 28th
(All Games Begin at 1:00 PM EST)
Tennessee Titans (0-3) T-3rd AFC South @ Houston Texans (0-3) T-3rd AFC South
- Location: NRG Stadium, Houston, Texas
- TV: CBS
- Odds: Texans -7.5; Over/Under 38.5 (via FanDuel sportsbook)
Philadelphia Eagles (3-0) 1st NFC East @ Tampa Bay Buccaneers (3-0) 1st NFC South
- Location: Raymond James Stadium, Tampa, Florida
- TV: FOX
- Odds: Eagles -3.5; Over/Under 44.5 (via FanDuel sportsbook)
Los Angeles Chargers (3-0) 1st AFC West @ New York Giants (0-3) 4th NFC East
- Location: MetLife Stadium, East Rutherford, New Jersey
- TV: CBS
- Odds: Chargers -6.5; Over/Under 43.5 (via FanDuel sportsbook)
Carolina Panthers (1-2) T-2nd NFC South @ New England Patriots (1-2) 2nd AFC East
- Location: Gillette Stadium, Foxborough, Massachusetts
- TV: FOX
- Odds: Patriots -5.5; Over/Under 43.5 (via FanDuel sportsbook)
Cleveland Browns (1-2) T-3rd AFC North @ Detroit Lions (2-1) T-1st NFC North
- Location: Ford Field, Detroit, Michigan
- TV: FOX
- Odds: Lions -9.5; Over/Under 44.5 (via FanDuel sportsbook)
New Orleans Saints (0-3) NFC South @ Buffalo Bills (3-0) 1st AFC East
- Location: Highmark Stadium, Orchard Park, New York
- TV: CBS
- Odds: Bills -14.5; Over/Under 48.5 (via FanDuel sportsbook)
Washington Commanders (2-1) 2nd NFC East @ Atlanta Falcons (1-2) T-2nd NFC South
- Location: Mercedes-Benz Stadium, Atlanta, Georgia
- TV: CBS
- Odds: Falcons -2.5; Over/Under 43.5 (via FanDuel sportsbook)