It’s game day, Bills Mafia! The Buffalo Bills (3-0) host the New Orleans Saints (0-3) this afternoon, and today’s edition of Buffalo Rumblinks has everything you need to know as the Bills look to open
the season 4-0 for the 10th time, and first time since the 2020 NFL season.

Predictions: Bills vs. Saints
Bills beat writers and NFL pundits break down the key matchups to watch and offer up their thoughts on how they see the Week 4 clash playing out.

- Bills vs. Saints expert picks: Is anyone predicting a New Orleans win over Buffalo? – Sports Illustrated Buffalo Bills
- Carucci Take 2: Bills know how to avoid trap of losing as overwhelming favorite – WGRZ
- Buffalo Bills vs. New Orleans Saints Game Predictions | Week 4 – BuffaloBills.com
- OPINION: Howard Picks the Bills: Week 4 – WGR 550
- Bills vs. Saints Game Preview: Top storyline, odds, player to watch & prediction – Sports Illustrated Buffalo Bills
- Beware this monster spread as Bills vs. Saints predictions come with warning – Democrat & Chronicle
- Four keys to Bills’ blowout victory over Saints in Week 4 – Sports Illustrated Buffalo Bills
- NFL Week 4 picks: The game of the week between two 1-2 teams? You bet – Buffalo News (subscription required)
- Pollock Preview and Predictions: Are the Buffalo Bills really favored by 16 1/2 points over the New Orleans Saints? – Wellsville Sun
- Our guide to every Week 4 NFL game: Matchup previews, predictions, picks and nuggets – ESPN.com
- Vic’s Picks, Week 4: Why Titans-Texans is the game of the week (yes, you read that right) – The Athletic (subscription required)
Latest Bills and Saints injury report
Bills starting defensive tackle Ed Oliver will miss the Saints game with an ankle injury, while linebacker Matt Milano will be sidelined with a pectoral injury, while starting right tackle Spencer Brown (calf) and defensive end A.J. Epenesa (pectoral) are questionable for Week 4. On the other sideline, the Saints will be without defensive end Chase Young (calf) and offensive tackle Dillon Radunz (toe), while wide receiver Devaugh Vele (hip) is questionable for the game.

- Bills notes: Right tackle Spencer Brown, defensive end A.J. Epenesa questionable – Buffalo News (subscription required)
- Bills to again be without DT Oliver, LB Milano – ESPN.com Buffalo Bills blog
- Buffalo Bills’ A.J. Epenesa details pec injury as game status vs. Saints remains uncertain – newyorkupstate.com
- Bills rule out 2 players ahead of Week 4 game vs. Saints – WGRZ
- McDermott makes it official, says Bills will be without two key defenders vs Saints – Democrat & Chronicle
- Bills upgrade Spencer Brown, making RT one of two questionable vs. Saints in Week 4 – Sports Illustrated Buffalo Bills
- Buffalo Bills injury report vs. Saints | Week 4 – BuffaloBills.com
- Sean McDermott confirms two Bills’ defensive starters will be out vs. Saints – Sports Illustrated Buffalo Bills
- Saints will be without game-changing pass rusher Sunday vs. Bills – Sports Illustrated Buffalo Bills
How to follow Bills vs. Saints from home
Not making the trip to Orchard Park for the game? No worries! We’ve got everything you need to follow today’s Week 4 clash vs. the Saints from the comfort of your couch.

- What channel is the Bills vs Saints game on? Time, TV, streaming – Democrat & Chronicle
- Buffalo Bills vs. New Orleans Saints | Where to watch, stream and listen | Week 4 – BuffaloBills.com
- Where to watch Bills vs. Saints: TV channel, live stream, prediction, pick, odds, spread – CBS Sports
Even more Bills news
Exploring how running back James Cook is delivering after signing his contract extension; Plus, whether wide receiver Curtis Samuel will ever make an impact this year; learn which veteran defensive tackle was elevated in advance of the Saints game; find out who will serve as Buffalo’s Legend of the Game; and more!

- James Cook is proving his worth after a back-and-forth contract negotiation this offseason – ESPN.com Buffalo Bills blog
- Bills Mailbag: Is Curtis Samuel ever going to get into the lineup? – Buffalo News (subscription required)
- Bills elevate Jordan Phillips ahead of Week 4 game vs. New Orleans – WGRZ
- Bills’ 33-year-old DT set to make season debut as Week 4 gameday call-up – Sports Illustrated Buffalo Bills
- Mitch Morse announced as Legend of the Game for Bills vs. Saints | Week 4 – BuffaloBills.com
- What Bills fans can expect at Highmark Stadium for Bills vs. Saints – BuffaloBills.com
- Saints vs Bills weather: Will it be as immaculate as Buffalo’s record? – Democrat & Chronicle
Buffalo Bills articles recently featured on Buffalo Rumblings
- Bills RB James Cook chasing franchise record Sunday – Buffalo Rumblings
- Some under-the-radar Bills could play key role vs. Saints – Buffalo Rumblings
- Bills elevate DT Jordan Phillips from practice squad – Buffalo Rumblings
- Bills vs. Saints, Week 4 broadcast map: Not a highly televised game – Buffalo Rumblings
- Bills vs. Saints NFL Week 4 referee assignment – Buffalo Rumblings
- WIngin’ It: Apples FallSkare for Saints at Bills – Buffalo Rumblings
- Journey to 100 straight Bills games: #85 —Thursday nights in Orchard Park – Buffalo Rumblings