Preseason football is finally over. The 2025 NFL regular season is finally at our doorsteps, with less than two weeks to go before kickoff officially begins. Each new season brings a renewed energy among all 32 NFL teams’ fanbases.
No one circles the wagons like Bills Mafia, and few teams find as favorable FanDuel Sportsbook odds in 2025 as the Buffalo Bills. With reigning NFL MVP Josh Allen at the helm, Buffalo will look to win the AFC East for a sixth consecutive time — further extending their current
franchise record (5 division titles in a row). The meter’s running, and head coach Sean McDermott’s looking for more.
Let’s dive into some of the odds for popular betting categories at FanDuel Sportsbook in case you want to wager some hard-earned cash!
Bills win totals
The pivot point for wins is between 11.5 and 12.5.
- Over 11.5 wins (-160)
- Under 11.5 wins (+135)
- Over 12.5 wins (+120)
- Under 12.5 wins (-140)
We already dove further into the Bills’ potential win totals in 2025, and I feel pretty confident saying that 12 wins feels both completely doable and necessary given Buffalo’s schedule this season. It’s a first-place finisher schedule, but perceptions (and ODDS) favor Buffalo in each matchup at this point.
AFC East winner
- Buffalo Bills (-260)
- New England Patriots (+500)
- Miami Dolphins (+700)
- New York Jets (+1700)
The Bills have won the AFC East the last five seasons, a new franchise record for consecutive division-winning campaigns. Until the rest of the division proves capable, the division belongs to Buffalo and Josh Allen.
Bills make/miss 2025 NFL playoffs
- Make playoffs (-800)
- Miss playoffs (+520)
The Bills (-800) carry the best odds among all 32 teams at making the playoffs (Baltimore Ravens are next at -520). Conversely, Buffalo (+520) holds the longest odds of missing the playoffs (Ravens also second here at +390). Consider this the NFL MVP effect.
Bills Super Bowl winner odds
- Bills to win Super Bowl (+750)
Buffalo has the current second-best odds to win Super Bowl LX, behind the Philadelphia Eagles (+700) and Ravens (+700).
The 2025 NFL season’s Super Bowl marks the 60th installment of the now-iconic game. If you’re a numbers person who believes in fate, the stars may be aligned in Buffalo’s favor for 2025, thanks to the number 60. As a franchise, the Bills began play in 1960, as one of the founding teams of the AFL. While that may prove to be best paired with a bridge to nowhere, it’s something to latch onto among those looking for signs.
Bills Super Bowl matchup odds
- Buffalo Bills vs. Philadelphia Eagles (+2000)
- Buffalo Bills vs. Detroit Lions (+2700)
- Buffalo Bills vs. Green Bay Packers (+4000)
- Buffalo Bills vs. Los Angeles Rams (+4000)
- Buffalo Bills vs. San Francisco 49ers (+4000)
- Buffalo Bills vs. Washington Commanders (+4000)
- Buffalo Bills vs. Minnesota Vikings (+4500)
These are Buffalo’s potential matchups carrying the most likely odds as of publishing. A lot can change in a season, and the matchups favor last season’s league results.
Season Leader milestones (Bills only)
Most Regular-Season Passing Yards 2025-26
- Josh Allen (+1500)
Most Regular-Season Passing TDs 2025-26
- Josh Allen (+1400)
Most Regular-Season Interceptions Thrown 2025-26
- Josh Allen (+2000)
Most Regular-Season Receiving Yards 2025-26
- Keon Coleman (+12500)
Most Regular-Season Receiving TDs 2025-26
- Keon Coleman (+7500)
Most Regular-Season Rushing Yards 2025-26
- James Cook (+2700)
Most Regular-Season Rushing TDs 2025-26
- Josh Allen (+1300)
- James Cook (+2200)
Player Milestones
4000+ Regular-Season Passing Yards 2025-26
- Josh Allen (+125)
750+ Regular-Season Rushing Yards 2025-26
- James Cook (-330)
1000+ Regular-Season Rushing Yards 2025-26
- James Cook (+100)
1250+ Regular-Season Rushing Yards 2025-26
- James Cook (+270)
To Throw 30+ Regular-Season Passing TDs 2025-26
- Josh Allen (+155)
To Throw 35+ Regular-Season Passing TDs 2025-26
- Josh Allen (+420)
To Throw 40+ Regular-Season Passing TDs 2025-26
- Josh Allen (+1200)
6+ Regular-Season Rushing TDs 2025-26
- James Cook (-450)
8+ Regular-Season Rushing TDs 2025-26
- Josh Allen (-300)
- James Cook (-210)
10+ Regular-Season Rushing TDs 2025-26
- Josh Allen (-155)
- James Cook (-115)
12+ Regular-Season Rushing TDs 2025-26
- Josh Allen (+120)
- James Cook (+150)
FanDuel Passing Props
Josh Allen Regular-Season Total Passing Yards 2025-26
- Over 3775.5 (-114)
- Under 3775.5 (-114)
Josh Allen Regular-Season Total Passing TDs 2025-26
- Over 27.5 (+112)
- Under 27.5 (-148)
FanDuel Rushing Props
James Cook Regular-Season Total Rushing Yards 2025-2
- Over 950.5 (-114)
- Under 950.5 (-114)
Josh Allen Regular-Season Total Rushing Yards 2025-26
- Over 500.5 (-114)
- Under 500.5 (-114)
Most Regular-Season Rushing TDs 2025-26
- Josh Allen (+1300)
- James Cook (+2000)
James Cook Regular-Season Total Rushing TDs 2025-26
- Over 8.5 (-140)
- Under 8.5 (+106)
Josh Allen Regular-Season Total Rushing TDs 2025-26
- Over 10.5 (-104)
- Under 10.5 (-128)
FanDuel Receiving Props
Most Regular-Season Receiving TDs 2025-26
- Keon Coleman (+7500)
FanDuel Sportsbook is holding a Flash Sale on Tuesday, August 26 where you can get profit boost tokens around various futures markets throughout the day. The markets will be split up throughout the day, but they will include odds to win the Super Bowl and hypothetical Super Bowl matchups, odds to make or miss the playoffs, win totals, division winners, and player milestones. Head over to FanDuel Sportsbook on Tuesday to take advantage.
