The Denver Broncos begin a streak of four out of five games on the road in Week 2. Every win in this stretch is going to be hugely important to them down the road and the Indianapolis Colts are a beatable team if Denver can play a sound football game on both sides of the ball. The line is tight in this game, so bettors think this is going to be a flip of the coin.
Game Overview
Denver Broncos at Indianapolis Colts Sunday, September 14, 2025 at 2:05 P.M. Mile High time Lucas Oil Stadium in Indianapolis, Indiana ATS
Betting Lines: Denver -2.5 Moneyline Odds: Denver -122 / Kansas City +104 Over/Under: 43.5 Note: All odds courtesy of FanDuel Sportsbook.
Collectively, our Mile High Report staff is predicting a Broncos 28-13 road win over the Colts in Week 2. We all predicted wins, but here is where we each landed individually on the score:
Broncos 21, Colts 16
The defense finally gives up a touchdown, but only field goals after that. Meanwhile, the Broncos offense finds some groove in this game and grinds out their first road win of the season. They need this 2-0 start, so they better go get it! – Tim Lynch
Broncos 24, Colts 17
The Broncos will have to improve on the offensive side of the ball if they want to take care of business on the road in Indianapolis. With a banged-up secondary, I expect Nix to be able to be fairly effective moving the ball through the air. However, a consistent running game would go a long way toward securing a victory. On defense, they need to contain Jonathan Taylor who scampered for over 100 yards against them last season and force Daniel Jones into some bad decisions. I expect this game to be close, but with Denver moving to 2-0 on the season. – Chris Hart
Broncos 24, Colts 10
Week one might have exposed some of the offensive flaws for the Broncos, but we saw a defense that has the potential to win games all on its own. The Colts looked like they were playing the Little Sisters of the Poor School for the Blind, so we learned nothing about them. By all accounts, Denver is likely the better team. They will clean things up on offense and the defense will look as good as they always do. – Adam Malnati
Broncos 30, Colts 13
I know for a fact that Daniel Jones will not light up the Denver defense like he did the Dolphins, so there’s one loose end already tied up. I also know this Colts defense doesn’t have what it takes to slow down the Dobbins and Harvey hype train. The offense is going to pick things up this week, moving on from the Titans, and the defense might just get even better. This shouldn’t be as close as last year was. – Ross Allen
Broncos 38, Colts 12
The Colts benefitted from playing a bad Dolphins team but this week, they and QB Daniel Jones turn into a pumpkin. The defense dominates, Jones turns the ball over multiple times and the Broncos offense led by Bo Nix and Troy Franklin take advantage of a beat up Colts secondary. We also see another RJ Harvey long run. – Scotty Payne
Broncos 31, Colts 10
This Broncos defense is legit. Like crazy good legit. They will make life hell for Jones on Sunday in Indy. While I don’t think Nix and the Denver offense will look and play like the PFM offense circa 2013, they will be better. We will see the Broncos more in sync, make better decisions, and just look sharper than they did in Week 1. And that includes more consistent plays in the running game from Dobbins and Harvey. I also have a feeling we’ll see a big (good) play from Denver’s special teams. – Ian St. Clair
Broncos 27, Colts 9
While I’m not as sure about this offense for the Broncos as last week, I am a full believer in this defense. We will see the better end of the turnover battle which will help the offense score. – Sadaraine
Broncos 31, Colts 16
The offense is going to finally go off on Sunday and the Colts OL is going to break. Daniel Jones will be running for his life as he will be forced to pass once the Broncos jump out to a large lead. – Joe Mahoney
