The 2-1 Jacksonville Jaguars head to San Francisco on Sunday, as the team looks toward their first road victory of 2025. Jacksonville will face the 3-0 San Francisco 49ers at 4:05 (EST) at Levi’s Stadium
in Santa Clara. On Wednesday, both teams released their initial injury reports for the week, with reasonably good news for Jacksonville.
Jacksonville Jaguars:
Jacksonville starting starting receiver Dyami Brown opened the week as a DNP after leaving Sunday’s matchup with a shoulder injury. When asked if Brown’s injury would be a longer-term or shorter-term injury, Head Coach Liam Coen responded “can’t tell you right now.”
Additionally, running back Bhayshul Tuten was a limited participant, wearing a red non-contact jersey on Wednesday as he continues to work back to full participation with a shoulder issue. Tuten was also limited in each of last week’s practices before suiting up against Houston, rushing 6 times for 21-yards and a touchdown (3.5 YPC).
Rookie offensive lineman Wyatt Milum was a limited participant as he recovers from his training camp knee injury that resulted in him missing the first three weeks of 2025. Patrick Mekari (elbow) and Ezra Cleveland (ankle) were both limited.
Wide receiver Brian Thomas Jr (wrist) was listed as a full participant on Wednesday.
San Francisco 49ers:
For San Francisco, the injury list is pretty extensive for week four with multiple star players either questionable or already ruled out for Sunday. Defensive end Nick Bosa will reportedly be out for the season with a torn ACL. Initial reports reflected that he will undergo surgery for this week 3 sustained injury. He has not officially been placed on IR or ruled out of the game, as of publishing.
Tight end George Kittle is also currently on the Injured Reserve with a hamstring injury. Receiver Brandon Aiyuk, continues to work his way back from last season’s ACL and MCL injuries, missing the first three games, as he is on the PUP List.
49ers quarterback Brock Purdy has missed two games due to a turf toe issue he has been working back from. He was limited on Wednesday.
Additionally, backup QB Mac Jones also has been dealing with a PCL (knee) injury since training camp that put him on the injury report entering week 3. He reaggravated his knee during their week 3 win and was limited on Wednesday as well. Coach Coen noted that Jacksonville would prepare for the possibility of facing either quarterback this week.
San Francisco’s leading receiver Ricky Pearsall (281-yards receiving) didn’t practice on Wednesday, but let the media know that he just had some knee soreness. Pearsall stated that his expectation is to practice this week and be good to go on Sunday. Wide receiver Jauan Jennings was also a DNP on Wednesday due to ankle and shoulder injuries after missing the week 3 game.
Rookie WR Jordan Watkins was a DNP and is expected expected to miss multiple weeks with a calf injury, per 49ers head coach Kyle Shanahan last week:
“You never know with calves, but guess around three to four,”
Defensive tackle CJ West will reportedly undergo thumb surgery for an injury suffered during the team’sweek 3 victory over the Arizona Cardinals. , Defensive lineman Yetur Gross-Matos missed Wednesday with a knee injury. He was also a DNP last Wednesday for this same injury before playing in Sunday’s matchup.
Cornerback Renardo Green (neck), cornerback Deommodore Lenoir (illness), and offensive lineman Connor Colby (groin) were all also limited for San Francisco on Wednesday.
As an aside, 49ers WR Demarcus Robinson, who was suspended for the first three games for violating the NFL’s personal conduct policy, is now eligible to play in Sunday’s matchup, to potentially give the San Francisco receiver corps a boost.
Overall, Wednesday’s injury report was reasonably positive to start to the week for a Jacksonville offense still awaiting clarity on Dyami Brown’s status. With Parker Washington looking primed for a larger role, in Dyami’s absence, earning 11-targets on Sunday, Jacksonville may have a few options available during any potential absence.
What are your thoughts on the week’s first injury report, Duval? Let us know in the comments!
