The Denver Broncos will be on the road in Week 4 to take on the undefeated San Francisco 49ers. Denver is fresh off back-to-back comeback wins to overcome double-digit deficits in each. They’ll need to play a much cleaner game this week and discover how to perform well in the first half for a change.
Kickoff is set for 2:25 p.m. Mile High time on Sunday, October 4, 2026 at Levi’s Stadium in Santa Clara, California. You can watch the live stream of the game through FuboTV or on CBS. The game will be called
by Kevin Harlan (play-by-play), Trent Green (analyst), and Melanie Collins (sideline). You can also check local Broncos radio network affiliate stations.
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Broncos vs. 49ers score predictions
This is one of those games where I think the Broncos won’t be able to catch fire late. A combination of the heat, poor starts, and inability to sustain drives will catch Denver sleeping. They will mount a late drive, but the defense is too tired to rally. It’s okay, though. Losing on the road to an NFC team is the “best” kind of loss and the Broncos will bounce-back to win the next two games anyway. 4-2 through the first six games was always my target.
49ers 27, Broncos 16.
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