The San Francisco 49ers’ official schedule is out. No more leaks, although they were spot on once again. The 49ers will travel to the East Coast twice this season. They’re fortunate enough to have a bye week after one of those trips, while the second one is sandwiched in between home games against the Seahawks and the Rams.
When you go through the schedule, it’s not a stretch to see this team winning double-digit games. That’s easy to say of May.
The 49ers will drop a game or two they have no business
losing, and will likely pull off a victory when their backs are against the wall. Let’s walk through the entire schedule.
Week 1: vs. Rams – Thursday, September 10, 5:35 p.m. PT
It’s a shame this will be an international game. We’re talking about two of the best teams in the league in arguably the best division in football. This game will be somewhat of a showcase offensively with Kyle Shanahan and Sean McVay calling plays on each sideline.
Brock Purdy will have some new toys to play with. He didn’t play against the Rams last season. Los Angeles also didn’t have to deal with Mike Evans, De’Zhaun Stribling, or Christian Kirk. This is a secondary that made Kendrick Bourne look like Anquan Boldin. The Rams will be much better in the secondary with Trent McDuffie and Jaylen Watson, both of whom were on the Chiefs last season.
Week 2: vs. Dolphins – Sunday, September 20, 1:25 p.m. PT
The 49ers’ home opener comes against Malik Willis and Miami. Willis’s targets consist of Jalen Tolbert, Tutu Atwell, Malik Washington, and a pair of rookie third-rounders. The Dolphins are also breaking in rookie Kadyn Proctor, although he’s playing next to an All-Pro center.
It should be a relatively soft landing spot in the home opener for Purdy and company. The Dolphins’ secondary consists of four journeymen and first-rounder Chris Johnson. There are a pair of first-round defensive linemen to deal with, but this is not a team that should contend in 2026.
Week 3: vs. Cardinals – Sunday, September 27, 1:05 p.m. PT
Win your home games. Win your home divisional games. That should be the motto for the 49ers in 2026. They’ll have a great opportunity to get off to a 2-0 start at home.
The Cardinals added a couple of veterans in free agency defensively, but only added two Day 3 picks to a defense that finished sixth-worst in the NFL in EPA per play with the fifth-lowest sack percentage.
Arizona added Jeremiyah Love and Chase Bisontis on offense. They also signed Isaac Seumalo to bolster their offensive line and Tyler Allgeier to improve the backfield.
It’s hard to imagine this team getting enough stops to contend with the upper-echelon teams of the league, even with an electric rookie like Love.
Week 4: vs. Broncos – Sunday, October 4, 1:25 p.m. PT
The third consecutive game at Levi’s Stadium comes against the team that probably felt that it should’ve made the Super Bowl last season.
Denver’s big offseason acquisition was trading for wide receiver Jaylen Waddle. Aside from losing Dre Greenlaw, the Broncos’ roster remains unchanged. Bo Nix gets another weapon, but that offense was tough to watch last season. Will Waddle make that much of a difference?
The Broncos were lights out defensively in 2025, but defense doesn’t always carry over. I think the Broncos take a step back in 2026. With that said, this’ll be a tremendous challenge for San Francisco’s wideouts.
Week 5: @ Seahawks – Sunday, October 11, 1:25 p.m. PT
The second road game of the season comes against the reigning Super Bowl champs. Of the top teams in the NFC West, Seattle feels like the obvious candidate to regress. They replaced Kenneth Walker with first-rounder Jadarian Price. The starting free safety might be a second-round rookie. Seattle’s defense was otherworldly last season. They got by offensively with one threat in the passing game. They also lost their offensive coordinator.
That’s not to say this won’t be an above-average team. Scoring a touchdown would be a step in the right direction for the 49ers against Seattle. The new weapons should allow that to happen.
Week 6: vs. Commanders – Monday, October 19, 5:15 p.m. PT
Another home game for the 49ers. May this one come against Brandon Aiyuk? That would make for a fascinating matchup on Monday Night Football. Jayden Daniels would certainly approve of the move.
Washington is hoping Daniels bounces back from a sophomore slump. That defense is essentially an entirely new team with potentially six new starters. By Week 6, they might have found their groove. We’ll believe it when we see it.
Week 7: @ Falcons – Sunday, October 25, 10:00 a.m. PT
Michael Penix? Tua Tagovailoa? Will it matter? Raheem Morris will want to get revenge on the team that let him go. Looking at their roster, it’s the other side of the ball where the 49ers should find success.
As long as Bijan Robinson is in a uniform, Atlanta will be difficult to stop. After seeing Kyle Pitts step up last year and Drake London, the 49ers could have some struggles, but the quarterback play should be uneven, which bodes well for the road team.
Week 8: BYE
The bye week comes smack dab in the middle of the schedule, as opposed to Week 14 last year.
Week 9: vs. Raiders – Sunday, November 8, 1:05 p.m. PT
Fernando Mendoza and the Raiders will get the 49ers fresh off the bye week. Again, win your home games, especially against a rookie quarterback, even if he was drafted No. 1 overall.
Week 10: @ Cowboys – Sunday, November 15, 1:25 p.m. PT
Don’t be surprised if this game is flexed into primetime. By November, these could be two of the best teams in the NFC. I’d expect a high-flying matchup between Dak Prescott and Brock Purdy.
Week 11: vs. Vikings – Sunday, November 22, 5:20 p.m. PT
The 49ers will head to Mexico City to take on the Vikings. Will this come against Kyler Murray? If so, Minnesota will probably be sitting pretty. If it’s JJ McCarthy, it’s about as good as you can ask for if you’re Kyle Shanahan.
Week 12: vs. Seahawks – Sunday, November 29, 1:25 p.m PT
Getting your rival, even if it’s at home, the week after an international game seems sub-optimal. Both teams are plenty familiar with each other, so there will be no surprises. Still, this may be a tougher spot than the earlier matchup in the season against Seattle.
Week 13: @ Giants – Sunday, December 6, 10:00 a.m PT
An early body clock game in what could be potential “weather,” a week after going against your rival won’t be fun. This feels like a classic letdown spot for the 49ers.
Week 14: vs. Rams – Sunday, December 13, 1:25 p.m. PT
The last game against the Rams might end up being one of the games of the year. Let’s say the 49ers do have a letdown spot the week prior in the Big Apple. They are going to want to take it out on their next opponent. What better team to do that against than the Rams?
Week 15: @ Chargers – Thursday, December 17, 5:15 p.m. PT
The Niners are heading back to Los Angeles and will probably get another home environment here. These two haven’t played.
Week 16: @ Kansas City Chiefs – Sunday, December 17, 1:25 p.m. PT
Back-to-back AFC West road matchups for the 49ers late in the season. Both teams should be playoff contenders at this point, and this one’s against a familiar foe, San Francisco hasn’t had much success against.
Week 17: vs. Philadelphia Eagles – Sunday, January 3, 5:20 p.m PT
We get back-to-back years with Week 17 bangers. Last year’s delivered with the 49ers beating the Bears in a high-scoring affair.
San Francisco beat Philly in a great playoff game this past year. Here comes another anticipated rematch.
Week 18: @ Arizona Cardinals – January 9/10, TBD
Week 18 is always an interesting week, with many teams already knowing their playoff fate. But the 49ers get one of their more favorable matchups after a brutal stretch to end the year with the Cardinals.
