The NFL Week 5 slate of Sunday games will cap off with a Sunday Night Football matchup between the New England Patriots (2-2) on the road against the Buffalo Bills (4-0).
The Patriots lead the all-time regular season series between these divisional rivals, 78-50-1, and the home team has won the past five meetings. They last faced off back in January 2025, with the Patriots winning at home, 23-16.
Here’s everything you need to know about tonight’s game.
New England Patriots vs. Buffalo Bills
TV Schedule
Game time: 8:20 PM EST
Channel: NBC
Date: Sunday,
October 5, 2025
Location: Highmark Stadium | Buffalo, NY
Announcers: Mike Tirico, Cris Collinsworth, Melissa Stark
Online Streaming
Odds via FanDuel
Odds via FanDuel
New England Patriots: +7.5 (+330)
Buffalo Bills: -7.5 (-420)
Over/under: 49.5 points
SB Nation Blogs
Patriots: www.PatsPulpit.com
Bills: www.BuffaloRumblings.com
This is an open thread — discuss the game in the comments below!
