The Arizona Cardinals are still the biggest week one underdogs in the NFL with a +9.5-point line for their game against the Los Angeles Chargers.
However, spreads are no fun.
Let’s look at the three of the best bets for the Arizona Cardinals 2026 opener against the Los Angeles Chargers, with all odds courtesy of our friends at FanDuel Sportsbook.
Jacoby Brissett over 1.5 passing touchdowns (+148)
The Arizona Cardinals may not win this game, but if they are going to score points it is likely going to be utilizing the tantalizing talents of their skill
players through the air. Brissett in his 11 starts threw two or more touchdowns in nine of them.
Trey McBride to record 25+ Receiving Yards in Each Half (+190)
McBride was briefly the highest paid tight end in the NFL, and Mike LaFleur has an affinity for using his tight ends as much as possible. This seems like an easy bet and no-brainer at those odds.
Marvin Harrison Jr. anytime touchdown scorer +250
Marv has looked excellent all camp, but especially in the redzone. If the Cardinals are able to get into the redzone, they will give Marv a couple of chances to make plays.
What are your favorite bets for the Cardinals/Chargers matchup?
