Jaguars vs. Bengals odds: Opening lines for Week 4 matchup

CINCINNATI, OHIO - SEPTEMBER 14: Ja'Marr Chase #1 of the Cincinnati Bengals runs with the ball during the game against the Jacksonville Jaguars at Paycor Stadium on September 14, 2025 in Cincinnati, Ohio. (Photo by Andy Lyons/Getty Images) | Getty Images The Jacksonville Jaguars are playing their se

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What is the story about?

The Jacksonville Jaguars are playing their second AFC North game of the season in Week 4 as they travel to Ohio to take on the Cincinnati Bengals.

The Jaguars (2-1) are coming off a glorious 29-point win against the Patriots, in which Trevor Lawrence threw 3 touchdowns, Parker Washington made multiple highlight catches, and Travis Hunter recorded his first interception. Are we sure that Drake Maye didn’t show up to the game drunk?

The Bengals (2-1) are coming off a bitter 3-point loss to the Steelers,

in which Aaron Rodgers turned back the clock to outduel Joe Burrow. Both quarterbacks threw 3 touchdowns, but Burrow was strip-sacked on the Bengals’ final drive, sealing the win for the Steelers.

According to FanDuel Sportsbook, the Jaguars are 2.5-point underdogs against the Bengals in Week 4. The total is set at 50.5 points.

What are your thoughts on the opening line, Jags fans? Do you trust Liam Coen and company to start a new win streak by toppling a fellow AFC contender? Or will Ja’Marr Chase and Tee Higgins overwhelm Hunter and the Jaguars’ secondary?

Let us know your thoughts in the comments below!