Continuing the two-part series evaluating one intriguing matchup from each of the Lions’ 17 games, this installment shifts focus to Weeks 10-18 after Part 1 covered the front half of the schedule earlier this week
.Keep in mind, this exercise is simply one avenue to begin providing analysis for each matchup. The selections are not necessarily the single most important matchup in every game, as I also wanted to avoid repeating the same Lions players or coaches throughout the series.
Below are the nine
intriguing matchups from the back half of the schedule—the portion of the season when the stakes rise, the weather worsens, and everything begins to feel far more real.
Week 10 — vs. New England Patriots
Kerby Joseph and Brian Branch vs. Drake Maye
Drake Maye operated as a strong MVP candidate last season despite not working with the strongest offensive supporting cast. Maye was especially lethal pushing the ball deep (20+ air yards), with Kayshon Boutte, Stefon Diggs, and DeMario Douglas all eclipsing 150 receiving yards on deep targets. On deep throws last season, Maye ranked second in completions (25), second in passer rating (128.5), second in yards per attempt (17.6), third in completion percentage over expectation (+13.9%), and first in EPA per dropback (+1.31).
There may not be a better safety duo on paper equipped to challenge Maye than Kerby Joseph and Brian Branch when healthy. Week 10 should serve as a strong checkpoint for both players physically, with hopes that Joseph had been fully back to himself before then and Branch beginning to regain his sea legs—even if it is still at a slightly reduced version of himself.
Joseph’s range as a center fielder can challenge Maye’s willingness to attack vertically, while Branch’s presence underneath creates a nightmare in the intermediate areas by erasing many of the efficient completions that keep offenses on schedule.
Week 11 — vs. Tampa Bay Buccaneers
Sam LaPorta vs. Alex Anzalone
Hello blondness, my old friend.
The Buccaneers-Lions interconference rivalry continues this season after four matchups over the last three years, with Detroit winning three of them and longtime Lions captain Alex Anzalone now joining the dark side.
Anzalone is a natural schematic fit with Todd Bowles, though Tampa Bay’s defense has regressed in each of the last two seasons and has failed to finish top 15 in points allowed per game during that span.
Still, the Buccaneers spent the offseason trying to reinforce the unit by adding players like Al-Quadin Muhammad, Reuben Bain Jr., Jeremiah Trotter Jr., Keionte Scott, and A’Shawn Robinson alongside Anzalone.
By Week 11, the Lions are hoping to have the Pro Bowl-caliber version of Sam LaPorta fully humming again. LaPorta’s ability to work the middle of the field, attack down the seam, and generate yards after the catch on underneath throws will make him a central piece of the offensive game plan—and one that Anzalone will likely spend plenty of time trying to contain.
Week 12 — vs. Chicago Bears
Kelvin Sheppard vs. Ben Johnson
The Lions’ annual Thanksgiving spectacle has not exactly provided much to be thankful for lately, with Detroit losing eight of its last nine Thanksgiving games. This year’s edition also comes at the tail end of a brutal stretch—their third game in less than two weeks following cross-Atlantic travel — with arch-nemesis Ben Johnson waiting at the finish line.
There are still plenty of outstanding questions surrounding how defensive coordinator Kelvin Sheppard wants this defense to operate in his second-year at the helm. Will the Lions lean more heavily into base or nickel personnel? Will Detroit mix in zone concepts more frequently? Could more Cover-3 or Cover-2 Man replace some of the heavy Cover-1 tendencies? And will the Lions more consistently prioritize personnel packages better equipped to generate pass rush?
By this point in the season, the Lions will hope Sheppard has found successful answers to many of those questions.
If his adjustments can help Detroit scheme up answers for Johnson’s offense and throw a few wrinkles at Caleb Williams and the Bears attack, it would go a long way toward allowing the Lions defense to dictate terms rather than react.
Week 13 — at Atlanta Falcons
Jameson Williams vs. Falcons secondary
The Falcons are once again navigating a regime change and still carry a fairly mediocre overall roster, but the back end of their defense quietly shows a lot of promise.
It’s a heady, rangy secondary led by A.J. Terrell and Jessie Bates, alongside veteran Mike Hughes and younger additions like Xavier Watts, Billy Bowman Jr., and Avieon Terrell. It’s also the type of personnel group defensive coordinator Jeff Ulbrich should be able to maximize into a respectable unit.
That makes this an intriguing challenge for Jameson Williams.
Whether it’s winning vertically or creating explosive yards-after-catch opportunities underneath, Williams finding ways to stress Atlanta’s secondary would open up Detroit’s offense as a whole.
The Falcons finished top 10 last season in deep passing EPA allowed per play and also ranked top 10 in fewest yards after catch allowed overall. If Williams can beat Atlanta in the exact areas where the defense is strongest, it would be a strong indicator of just how dangerous Detroit’s offense can become late in the season.
Week 14 — vs. Tennessee Titans
Cade Mays vs. Jeffery Simmons
There is plenty of intrigue surrounding what new Titans coach Robert Saleh can do with a retooled defense anchored by veteran defensive tackle Jeffery Simmons.
“Big Jeff” remains arguably one of the 10 most talented and disruptive defensive players in football and feels primed for another dominant season, alongside additions like John Franklin-Myers, Jermaine Johnson II, Keldric Faulk, and Solomon Thomas across the defensive front.
While the Lions hope both Tate Ratledge and Christian Mahogany are significantly improved and firmly entrenched as above-average starters by December, this matchup will also require plenty of involvement from Cade Mays. Even when Simmons is not directly aligned over the center, Mays will need to remain constantly aware of where he is located pre-snap and be prepared to help neutralize him however possible.
If Detroit can successfully contain Simmons, the offense should have an opportunity to put together a highly productive day on the scoreboard.
Week 15 — at Minnesota Vikings
Amon-Ra St. Brown vs. Byron Murphy
Any discussion involving the Vikings matchup begins and ends with trying to solve Brian Flores’ defense, despite the presence of talented offensive head coach Kevin O’Connell on the opposite sideline.
In four games against Minnesota during the 2023 and 2024 seasons, Amon-Ra St. Brown averaged 9.75 targets, 8.25 receptions, 109.75 receiving yards, 0.75 touchdowns, six first downs, and a staggering 69.2% receiving success rate per game.
Then last season, amid Detroit’s disastrous offensive answers against the Vikings defense, those numbers cratered. St. Brown averaged 13 targets, 8.5 receptions, 82.5 receiving yards, zero touchdowns, 3.5 first downs, and just a 46.2% receiving success rate. Forced inefficiency.
A large portion of that stemmed from Detroit’s offense as a whole repeatedly losing both pre-snap and immediately post-snap due to being out-schemed and failing to find consistent counters, but some of it can also be attributed to the challenge of dealing with Byron Murphy Jr. and the variety of defenders Flores rotates onto St. Brown.
Murphy remains one of the league’s more skilled slot defenders. But if St. Brown can become a comfortable, reliable outlet for Jared Goff, it could be the straw that stirs Detroit’s offense against one of the NFL’s most difficult defenses to consistently attack.
Week 16 — vs. New York Giants
Derrick Moore & DJ Wonnum vs. Andrew Thomas
This matchup is about getting revenge for Detroit’s embarrassing defensive showing at Ford Field in 2025, when the Giants dropped 27 points behind Jameis Winston.
New York’s offense features an intriguing collection of skill talent, but its ceiling ultimately comes down to whether the Giants can finally field a formidable offensive line led by their best player, Andrew Thomas. With Aidan Hutchinson still expected to align more frequently on the defense’s left side, that leaves recent Lions investments Derrick Moore and DJ Wonnum likely seeing plenty of work against Thomas.
Both defenders will need to stay disciplined against the sleight-of-hand elements of the read-option game with Jaxson Dart, hold up versus New York’s downhill rushing attack running behind Thomas, and most importantly, find ways to generate pressure against one of the league’s premier tackles.
Replacing the pass-rush impact previously provided by Al-Quadin Muhammad remains an important objective for Detroit’s defense, and if Moore, Wonnum, or both can emerge as dependable secondary pass-rush threats opposite Hutchinson by late December, it would be a major development for Detroit’s hopes of securing the division and making a serious postseason push.
Week 17 — at Chicago Bears
Aidan Hutchinson vs. Darnell Wright
Now for that previously mentioned Aidan Hutchinson. Getting a clearer picture of where he is at—two years removed from the gruesome broken leg—could be one of the most important indicators of Detroit’s ability to make a true Lombardi run.
Seeing Hutchinson operate at full strength against one of the league’s better right tackles in Darnell Wright would validate his status as a true game-wrecker—the type of defensive force capable of tilting a game on his own and crippling pocket confidence against quarterbacks like Caleb Williams.
Week 18 — at Green Bay Packers
Jared Goff vs. Jonathan Gannon’s defense
Goff has historically struggled against Jonathan Gannon-led defenses, dating back to matchups with the Eagles in 2021 and 2022 and the Cardinals in 2024. Across those three games, Goff averaged just under 200 passing yards per game, took nearly three sacks per contest, threw multiple interceptions—including a pick-six—and averaged a pedestrian 6.8 yards per attempt.
If Goff can operate as one of the league’s most decisive and efficient passers in a high-stakes environment, it could propel Detroit’s postseason push in what may ultimately be another Week 18 primetime regular-season finale.
