Without a ton of obvious can't-miss games on the schedule, is Week 11 of the college football season shaping up to feature a series of upsets and letdown games?
Arguably the biggest game on the Week 11 schedule takes place in Bloomington, Indiana, where Lincoln Riley and 14th-ranked Southern California will take on Curt Cignetti's fifth-ranked, defending national champion Indiana team. Cignetti has not yet committed to who will play quarterback and, despite the Hoosiers' defensive acumen, will have a test against the Trojans' offense.
Elsewhere, Lane Kiffin and No. 22 LSU will look to bounce back from a humbling home loss to Alabama when Arch Manning
and No. 8 Texas travel to Baton Rouge, Louisiana.
Here's how USA TODAY's college football experts are picking those games and more:
College football Week 11 top-25 predictions, picks
Odds courtesy of BetMGM as of Tuesday, Nov. 10
Missouri at No. 1 Georgia
- Spread: Georgia (-15.5)
- Over/under: 47.5 points
- Moneyline: Georgia (-285) | Missouri (+230)
- Craig Meyer: Georgia 38, Missouri 20
- Austin Curtright: Georgia 38, Missouri 14
- John Leuzzi: Georgia 35, Missouri 20
- Jordan Mendoza: Georgia 38, Missouri 13
- Adam Bittner: Georgia 29, Missouri 20
What our experts think: "Georgia looks unbeatable right now, and its upset loss to Auburn might've been the wake-up call the Bulldogs needed. Missouri won't stand in Georgia's way." — Austin Curtright, USA TODAY
No. 2 Utah at No. 21 Arizona
- Spread: Utah (-2.5)
- Over/under: 54.5 points
- Moneyline: Utah (-140) | Arizona (+115)
- Craig Meyer: Utah 31, Arizona 23
- Austin Curtright: Utah 34, Arizona 24
- John Leuzzi: Utah 24, Arizona 20
- Jordan Mendoza: Utah 24, Arizona 23
- Adam Bittner: Utah 32, Arizona 28
What our experts think: "Utah's dual-threat quarterback Devon Dampier proves too much for Arizona's defense to stop in the end. The Wildcats' hopes of playing in the Big 12 title game become harder. Utah's defense comes up with a pair of takeaways." — John Leuzzi, USA TODAY
Boston College at No. 3 Notre Dame
- Spread: Notre Dame (-29)
- Over/under: 52.5 points
- Moneyline: Notre Dame (-5000) | Boston College (+2200)
- Craig Meyer: Notre Dame 48, Boston College 10
- Austin Curtright: Notre Dame 42, Boston College 7
- John Leuzzi: Notre Dame 31, Boston College 10
- Jordan Mendoza: Notre Dame 42, Boston College 17
- Adam Bittner: Notre Dame 41, Boston College 10
What our experts think: "This won't be a repeat of 1993, when Notre Dame beat a top-ranked team only to fall at home to Boston College a week later. The Eagles have been a surprisingly plucky team this year, but they're totally overmatched here. David Gordon isn't walking through that door." — Craig Meyer, USA TODAY
Illinois at No. 4 UCLA
- Spread: UCLA (-10)
- Over/under: 47.5 points
- Moneyline: UCLA (-375) | Illinois (+310)
- Craig Meyer: UCLA 27, Illinois 16
- Austin Curtright: UCLA 27, Illinois 24
- John Leuzzi: UCLA 20, Illinois 14
- Jordan Mendoza: UCLA 30, Illinois 18
- Adam Bittner: Illinois 26, UCLA 17
What our experts think: "The win over Minnesota was the best vote of confidence UCLA’s offense can lead the way. Going against one of the worst passing defenses in the country, Ty Dieffenbach has another great game to keep the Bruins undefeated and one game closer to the Big Ten title game." — Jordan Mendoza, USA TODAY
No. 14 USC at No. 5 Indiana
- Spread: Indiana (-7.5)
- Over/under: 49.5 points
- Moneyline: Indiana (-285) | USC (+230)
- Craig Meyer: USC 27, Indiana 23
- Austin Curtright: Indiana 28, USC 24
- John Leuzzi: USC 27, Indiana 24
- Jordan Mendoza: USC 23, Indiana 20
- Adam Bittner: Indiana 27, USC 25
What our experts think: "Indiana’s defense has carried the way for the horrid offense, but it will have problems trying to stop a USC offense that is clicking with its top playmakers healthy. The Trojans go into hostile territory and get a major win that puts USC right in the driver’s seat for the playoff." — Jordan Mendoza, USA TODAY
Duke at No. 6 Miami
- Spread: Miami (-13)
- Over/under: 54.5 points
- Moneyline: Miami (-525) | Duke (+400)
- Craig Meyer: Miami 34, Duke 19
- Austin Curtright: Miami 38, Duke 35
- John Leuzzi: Miami 34, Duke 21
- Jordan Mendoza: Miami 38, Duke 23
- Adam Bittner: Miami 30, Duke 24
What our experts think: "Punching back the way the Hurricanes did without Malachi Toney against Notre Dame gives reason for hope that this team will prevail in a game that looks like a classic potential letdown spot on paper. The Blue Devils are the reigning conference champs, consistent again in 2026 and know Miami QB Darian Mensah well as his former program. They’re dangerous, but look for Miami to re-assert itself." — Adam Bittner, USA TODAY
No. 7 Alabama at Vanderbilt
- Spread: Alabama (-15.5)
- Over/under: 50.5 points
- Moneyline: Alabama (-750) | Vanderbilt (+575)
- Craig Meyer: Alabama 45, Vanderbilt 16
- Austin Curtright: Alabama 49, Vanderbilt 14
- John Leuzzi: Alabama 38, Vanderbilt 14
- Jordan Mendoza: Alabama 42, Vanderbilt 16
- Adam Bittner: Alabama 34, Vanderbilt 19
What our experts think: "Vanderbilt is probably the worst team in the SEC, and Alabama is rolling right now heading into the final stretch after dominating LSU. The Crimson Tide win easy behind a big performance from Keelon Russell." — Austin Curtright, USA TODAY
No. 8 Texas at No. 22 LSU
- Spread: LSU (-4)
- Over/under: 45.5 points
- Moneyline: LSU (-185) | Texas (+150)
- Craig Meyer: Texas 30, LSU 27
- Austin Curtright: Texas 24, LSU 23
- John Leuzzi: Texas 31, Texas 28
- Jordan Mendoza: Texas 27, LSU 24
- Adam Bittner: Texas 30, LSU 20
What our experts think: "It hasn't always been particularly pretty or impressive, but Texas continues to pull out some workmanlike wins in games It absolutely needed after dropping two in a row in the middle of the season. Expect that to continue against a shaky LSU squad." — Craig Meyer, USA TODAY
No. 9 Tennessee at Texas A&M
- Spread: Tennessee (-2.5)
- Over/under: 43.5 points
- Moneyline: Tennessee (-140) | Texas A&M (+115)
- Craig Meyer: Tennessee 23, Texas A&M 6
- Austin Curtright: Tennessee 20, Texas A&M 7
- John Leuzzi: Tennessee 24, Texas A&M 17
- Jordan Mendoza: Tennessee 24, Texas A&M 10
- Adam Bittner: Tennessee 24, Texas A&M 13
What our experts think: "Tennessee avoids a setback to its path to the College Football Playoff with a win on the road. George MacIntyre finally throws for a touchdown after three straight games without one. Texas A&M's struggles continue." — John Leuzzi, USA TODAY
No. 10 Texas Tech at Oklahoma State
- Spread: Oklahoma State (-3.5)
- Over/under: 72.5 points
- Moneyline: Oklahoma State (-165) | Texas Tech (+140)
- Craig Meyer: Oklahoma State 41, Texas Tech 39
- Austin Curtright: Oklahoma State 41, Texas Tech 38
- John Leuzzi: Oklahoma State 42, Texas Tech 35
- Jordan Mendoza: Oklahoma State 48, Texas Tech 45
- Adam Bittner: Oklahoma State 38, Texas Tech 28
What our experts think: "Texas Tech doesn't have the same defense it had last season. Pair that with a rocking Boone-Pickens Stadium, and that'll be enough for an upset. Drew Mestemaker throws for five touchdowns as first-year coach Eric Morris beats his alma mater." — Austin Curtright, USA TODAY
No. 11 Wake Forest at No. 23 SMU
- Spread: Wake Forest (-1)
- Over/under: 61.5 points
- Moneyline: Wake Forest (-110) | SMU (+108)
- Craig Meyer: SMU 37, Wake Forest 34
- Austin Curtright: Wake Forest 38, SMU 30
- John Leuzzi: Wake Forest 38, SMU 27
- Jordan Mendoza: Wake Forest 40, SMU 35
- Adam Bittner: Wake Forest 32, SMU 27
What our experts think: "Mustangs quarterback Kevin Jennings has been really good, but mortal at the wrong times in 2026. Demon Deacons counterpart Gio Lopez has been a machine, even as he has battled injury concerns along the way. Look for him to keep humming and force Jennings to make too many plays to beat him." — Adam Bittner, USA TODAY
Baylor at No. 12 BYU
- Spread: BYU (-7.5)
- Over/under: 49.5 points
- Moneyline: BYU (-275) | Baylor (+230)
- Craig Meyer: BYU 24, Baylor 23
- Austin Curtright: BYU 28, Baylor 17
- John Leuzzi: BYU 28, Baylor 21
- Jordan Mendoza: BYU 26, Baylor 21
- Adam Bittner: BYU 31, Baylor 24
What our experts think: "The Cougars are getting a Baylor team that has found momentum after firing Dave Aranda, and they need to right the ship to keep the playoff hopes alive. DJ Lagway will keep the Bears close but BYU’s defense comes up strong in the fourth quarter to prevent the upset." — Jordan Mendoza, USA TODAY
Florida at No. 13 Kentucky
- Spread: Kentucky (-3.5)
- Over/under: 52.5 points
- Moneyline: Kentucky (-175) | Florida (+140)
- Craig Meyer: Kentucky 33, Florida 27
- Austin Curtright: Florida 30, Kentucky 27
- John Leuzzi: Kentucky 24, Florida 21
- Jordan Mendoza: Kentucky 31, Florida 27
- Adam Bittner: Kentucky 27, Florida 16
What our experts think: "Don't look now, but after losing to Florida 31 consecutive times, Kentucky is actually 5-3 in its past eight games against the Gators. Will Stein's squad will bounce back from a ghastly loss at Tennessee to earn a home win against a befuddling Florida team." — Craig Meyer, USA TODAY
Purdue at No. 15 Iowa
- Spread: Iowa (-17)
- Over/under: 47.5 points
- Moneyline: Iowa (-900) | Purdue (+650)
- Craig Meyer: Iowa 31, Purdue 16
- Austin Curtright: Iowa 24, Purdue 7
- John Leuzzi: Iowa 20, Purdue 17
- Jordan Mendoza: Iowa 23, Purdue 10
- Adam Bittner: Purdue 27, Iowa 20
What our experts think: "Boilermakers quarterback Ryan Browne and running back Fame Ijeboi feel like too good a duo not to put a scare into someone out of nowhere over this final month of games against good-to-great Big Ten foes. Why not a Hawkeyes team that you’re never quite ready to truly trust offensively?" — Adam Bittner, USA TODAY
No. 16 Houston at Colorado
- Spread: Houston (-9.5)
- Over/under: 51.5 points
- Moneyline: Houston (-375) | Colorado (+310)
- Craig Meyer: Houston 38, Colorado 17
- Austin Curtright: Houston 38, Colorado 14
- John Leuzzi: Houston 35, Colorado 20
- Jordan Mendoza: Houston 33, Colorado 16
- Adam Bittner: Houston 36, Colorado 20
What our experts think: "Colorado has been squirrely at home this season, even in games in which it's overmatched, but Houston's simply better in every facet of the game. The Cougars win big and make the Buffs' Deion Sanders predicament even more awkward." — Craig Meyer, USA TODAY
No. 17 Ole Miss at Oklahoma
- Spread: Ole Miss (-1)
- Over/under: 49.5 points
- Moneyline: Ole Miss (-110) | Oklahoma (-108)
- Craig Meyer: Ole Miss 24, Oklahoma 19
- Austin Curtright: Ole Miss 27, Oklahoma 23
- John Leuzzi: Ole Miss 27, Oklahoma 20
- Jordan Mendoza: Ole Miss 34, Oklahoma 17
- Adam Bittner: Oklahoma 28, Ole Miss 24
What our experts think: "" — John Leuzzi, USA TODAY
Oregon State at No. 18 Boise State
- Spread: Boise State (-13.5)
- Over/under: 65.5 points
- Moneyline: Boise State (-525) | Oregon State(+400)
- Craig Meyer: Boise State 38, Oregon State 23
- Austin Curtright: Boise State 35, Oregon State 27
- John Leuzzi: Boise State 38, Oregon State 28
- Jordan Mendoza: Oregon State 34, Boise State 33
- Adam Bittner: Boise State 35, Oregon State 30
What our experts think: "Oregon State will be tough to slow down with Braden Atkinson and Jesse Legree. That duo provides a spark but ultimately won't be enough to take down Boise State, especially with 'College GameDay' in town." — Austin Curtright, USA TODAY
Michigan at No. 19 Oregon
- Spread: Oregon (-11)
- Over/under: 38.5 points
- Moneyline: Oregon (-450) | Michigan (+340)
- Craig Meyer: Oregon 27, Michigan 10
- Austin Curtright: Oregon 20, Michigan 10
- John Leuzzi: Oregon 34, Michigan 14
- Jordan Mendoza: Oregon 23, Michigan 9
- Adam Bittner: Oregon 32, Michigan 17
What our experts think: "Teams trending in complete opposite directions, Michigan is going to have a tough time trying to handle the hostile crowd in Autzen Stadium. The Ducks comfortably win their third straight game and remain in the playoff hunt." — Jordan Mendoza, USA TODAY
Northwestern at No. 20 Ohio State
- Spread: Ohio State (-12.5)
- Over/under: 45.5 points
- Moneyline: Ohio State (-475) | Northwestern (+375)
- Craig Meyer: Ohio State 24, Northwestern 16
- Austin Curtright: Ohio State 30, Northwestern 17
- John Leuzzi: Ohio State 30, Northwestern 14
- Jordan Mendoza: Ohio State 20, Northwestern 17
- Adam Bittner: Northwestern 27, Ohio State 20
What our experts think: "If Aidan Chiles plays, the Wildcats absolutely have a chance against a wounded Buckeyes squad. Otherwise, this might be two depleted offenses in a close, but painful-to-watch game." — Craig Meyer, USA TODAY
No. 24 South Carolina at Arkansas
- Spread: South Carolina (-7.5)
- Over/under: 51.5 points
- Moneyline: South Carolina (-295) | Arkansas (+240)
- Craig Meyer: South Carolina 30, Arkansas 26
- Austin Curtright: South Carolina 42, Arkansas 20
- John Leuzzi: South Carolina 27, Arkansas 17
- Jordan Mendoza: South Carolina 33, Arkansas 21
- Adam Bittner: South Carolina 33, Arkansas 17
What our experts think: "South Carolina continues its late-season run through the SEC with its fifth consecutive win. The health status of LaNorris Sellers will be important in this one after getting banged up twice last week against Texas A&M." — John Leuzzi, USA TODAY
UNLV at No. 25 New Mexico
- Spread: New Mexico (-14)
- Over/under: 46.5 points
- Moneyline: New Mexico (-600) | UNLV (+450)
- Craig Meyer: New Mexico 23, UNLV 14
- Austin Curtright: New Mexico 20, UNLV 6
- John Leuzzi: New Mexico 35, UNLV 10
- Jordan Mendoza: New Mexico 24, UNLV 14
- Adam Bittner: New Mexico 29, UNLV 27
What our experts think: "The Rebels are averaging just a hair over 31 points over their past six games. The Lobos and quarterback Toa Fa'avae will need to have an answer for that firepower. We’ll give them the benefit of the doubt in this one despite seven picks from Fa'avae over his past five games." — Adam Bittner, USA TODAY
This article originally appeared on USA TODAY: College football picks: Week 11 expert predictions for USC-Indiana, Texas-LSU, more
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