Rams vs Bills odds, moneyline, over/under
Opening lines:
- Spread: Rams -3
- Moneyline: Rams -170; Bills +142
- Total: 53.5
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Rams vs Bills expert picks
Adam Kaufman: Rams 30, Bills 27
A pair of MVPs, Josh Allen against Matthew Stafford on Monday night? Yes, please. Buffalo needs a response after losing to New England, while Los Angeles just reminded Philadelphia that a 10-point fourth-quarter lead ain't what it used to be. I expect both quarterbacks to create explosive plays, but the Rams have a chance to make Allen's work harder if Aaron Donald returns. DJ Moore's shoulder is another important variable for the Bills' offense. I slightly prefer LA's ability to sustain drives at home. This should come down to a late possession, just as you'd hope between a pair of Super Bowl contenders.
Michael Middlehurst-Schwartz: Bills 28, Rams 27
Both Buffalo and Los Angeles are facing something of a reckoning after early
expectations of each team got a bit out of hand. Los Angeles looks like a far cry from the superteam it was billed as over the summer, but cutting down on turnovers and other self-imposed mistakes could go a long way toward returning the team to the league's elite tier of contenders. The Bills have been living dangerously themselves, especially on a defense that seems entirely reliant on drive- and game-flipping plays. Trotting out struggling cornerback Maxwell Hairston against Puka Nacua and Davante Adams might leave a distinct sense of unease for the Bills, but Joe Brady and Co. might be able to institute sufficient guardrails and engineer enough big plays to escape with the win.
Blake Schuster: Bills 37, Rams 28
Two teams looking to quiet the noise around them. Two defenses that have already been burned this season. Two quarterbacks who can sling it better than anyone else right now. Get your popcorn ready and say a prayer for the scoreboard operator.
Where to watch Bills at Rams
- Matchup: Rams vs. Bills
- Date: Oct. 12
- Time: 8:15 p.m.
- Venue: SoFi Stadium
- Location: Inglewood, California
- TV: ESPN, ABC
NFL Week 5 picks and predictions
- Buccaneers at Cowboys
- Texans at Titans
- Bengals at Dolphins
- Colts at Steelers
- Eagles at Jaguars
- Raiders at Patriots
- Vikings at Saints
- Giants at Commanders
- Browns at Jets
- Bears at Packers
- 49ers at Seahawks
- Broncos at Chargers
- Lions at Cardinals
- Ravens at Falcons
- Bills at Rams
This article originally appeared on USA TODAY: Bills at Rams: Predictions, picks and odds for NFL Week 5 game
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