The Los Angeles Rams return home Monday, Sept. 21, with an opportunity to secure their first victory of the season.
They will host the New York Giants at SoFi Stadium for "Monday Night Football."
Aaron Donald is slated to make his return in a Rams uniform for the first time since 2023. Donald had retired from the NFL but returned
to join a defense that has star power and potential to help lead Los Angeles back to the Super Bowl.Giants rookie right guard Francis Mauigoa is expected to be the primary matchup on Donald. It will serve as a bit of a homecoming for Mauigoa, who spent some time playing high school football at Aquinas High School in San Bernardino, California.
Quarterback Matthew Stafford and the offensive line will have to bounce back from
a lackluster loss in the season opener but will face a tough challenge again this week with Kayvon Thibodeaux and the New York pass rush.
Here's everything to know about the Week 2 "Monday Night Football" game, from start time to betting odds:
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What time does Rams vs Giants NFL game start?
The Rams and Giants game will kick off at 8:15 p.m. ET (5:15 p.m. PT) on Monday, Sept. 21.
It will be the final game of the Week 2 slate. The Rams will host it at SoFi Stadium just 11 days after the loss to the San Francisco 49ers in Australia. The Giants are coming off a 28-20 victory over the Dallas Cowboys in Week 1 on "Sunday Night Football."
What TV channel is Los Angeles Rams vs New York Giants on tonight?
The Rams vs. Giants game will be broadcast on ESPN on Monday night.
Rams vs Giants live stream
- Live stream: ESPN or Fubo
Cord-cutters can also stream the game on ESPN+ or Fubo, which offers a free trial.
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Rams vs Giants predictions, picks, odds
Odds courtesy of BetMGM Sportsbook as of Monday, Sept. 21.
- Rams 28, Giants 17: "It's probably time to reel it back in a bit after Week 1. Yes, the Rams' opening statement was certainly concerning. But even with Myles Garrett out of the fold, the Giants' Week 1 performance will be difficult to replicate against an outfit more competent than the Cowboys. So long as Matthew Stafford can avoid the repeated third-and-long looks that could unleash the Giants' pass rush, Los Angeles should be able to rediscover its comfort zone against New York." – Michael Middlehurst-Schwartz
- Spread: Rams -7
- Over/under: 47.5
- Moneyline: Rams (-300), Giants (+250)
This article originally appeared on USA TODAY: What channel is Rams vs. Giants for 'Monday Night Football'?













