49ers vs Broncos odds, moneyline, over/under
Opening lines:
- Spread: 49ers -1.5
- Moneyline: 49ers -145; Broncos +125
- Total: 47.5
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49ers vs Broncos expert picks
Adam Kaufman: 49ers 27, Broncos 24
It's early, but the undefeated 49ers look like one of football's best teams. The question is how long they can keep winning through all these injuries. Nick Bosa will miss Sunday's game, while Mike Evans and Trent Williams left the latest win over Arizona. Both could return against Denver, but their status bears watching. Brock Purdy has kept San Francisco's offense rolling regardless, throwing four touchdowns against the Cardinals. The Broncos have pulled off consecutive double-digit comebacks against the Jaguars and Rams. Impressive? Absolutely. A formula I trust on the road against this 49ers offense? Not quite. Give me San Francisco in a close one.
Michael Middlehurst-Schwartz: 49ers 31, Broncos 21
Fresh off his two-interception
star turn in prime time, Talanoa Hufanga squares off against his former team in San Francisco. The safety's playmaking prowess could be an essential factor in keeping a lid on the 49ers, who rank second in scoring and have nearly double the EPA/play of the next closest team. Mounting injuries leave a distinct sense of unease for Kyle Shanahan's crew, but Denver will be hard-pressed to throw Brock Purdy off his game.
Nicholas Brinkerhoff: 49ers 26, Broncos 21
Injuries remain a concern for the Niners, but the Broncos still haven't played a complete game in 2026. So what should you make of both teams? Brock Purdy is playing like an MVP candidate, even as the players around him drop like flies. And that is the difference in this game. As long as No. 13 stays healthy, it's hard to not like San Francisco's chances. Denver has played with fire for weeks. The Broncos get burned in Week 4 and realize that NFL games are more than 30 minutes.
Where to watch Broncos at 49ers
- Matchup: 49ers vs. Broncos
- Date: Oct. 4
- Time: 4:25 p.m.
- Venue: Levi's Stadium
- Location: Santa Clara, California
- TV: CBS
NFL Week 4 picks and predictions
- Steelers at Browns
- Colts at Commanders
- Patriots at Bills
- Jaguars at Bengals
- Packers at Buccaneers
- Titans at Ravens
- Rams at Eagles
- Cardinals at Giants
- Jets at Bears
- Cowboys at Texans
- Dolphins at Vikings
- Broncos at 49ers
- Chiefs at Raiders
- Chargers at Seahawks
- Lions at Panthers
- Falcons at Saints
This article originally appeared on USA TODAY: Broncos at 49ers: Predictions, picks and odds for NFL Week 4 game
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