1. One of the league's most storied non-divisional rivalries has been rather lopsided as of late. San Francisco has won the last four meetings between the two teams.
2. Injuries continue to loom large for San Francisco's shorthanded receiving corps. Coach Kyle Shanahan said Mike Evans is not expected to return from Achilles tendinitis this week, though the team does expect to have Deebo Samuel back. San Francisco also added veteran Keenan Allen at the trade deadline.
3. The Cowboys have their own health concerns clouding their short-term outlook. Both wide receiver George Pickens (hamstring) and cornerback Joey Porter Jr. (foot) appear to be in wait-and-see situations for this week.
Cowboys vs 49ers odds, moneyline, over/under
Opening lines:
- Spread: Cowboys (-1.5)
- Moneyline: Cowboys -120; 49ers +100
- Total: 52.5
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Cowboys vs 49ers USA TODAY expert picks
Adam Kaufman: 49ers 31, Cowboys 24
Dallas outgained Indianapolis by more than 200 yards last week and still barely won. Fourteen penalties will do that. The Cowboys can move the ball against the 49ers, especially if George Pickens' hamstring cooperates and the visitors are still banged up in the secondary. I have a much harder time seeing Dallas get enough stops. Christian McCaffrey scored on the ground and through the air last week, and San Francisco ran for 190 yards to blitz Las Vegas. If Dallas has to commit extra help to stop McCaffrey, Brock Purdy will have openings downfield – maybe even in the form of new toy Keenan Allen. The Cowboys are capable of hanging around at home. They won't win.
Michael Middlehurst-Schwartz: 49ers 28, Cowboys 16
Closing out games has been a problem for Dallas this season. That might not come into factor here ... But only because San Francisco could run away with this one. Even a shorthanded version of the 49ers offense should be able to push Christian Parker's defense into uncomfortable positions. Meanwhile, Brian Schottenheimer's attack could be in for a tough day if it hits any more cold stretches.
Nicholas Brinkerhoff: 49ers 34, Cowboys 23
The 49ers are just in a different class, even with the injuries. Kyle Shanahan should have his way with this Dallas defense, which barely scraped by the lowly Colts last week. When things are going right, the Cowboys light up the scoreboard – except nothing has gone right this season. It's hard to believe a step up in competition is going to do the Cowboys any favors against a 49ers team that just added some reinforcements at the trade deadline to prepare for a long playoff run.
Where to watch 49ers at Cowboys
- Matchup: Cowboys vs. 49ers
- Date: Nov. 15
- Time: 4:25 p.m.
- Venue: AT&T Stadium
- Location: Arlington, Texas
- TV: Fox
49ers at Cowboys updated injury report
This article originally appeared on USA TODAY: 49ers at Cowboys: Predictions, picks and odds for NFL Week 10 game
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