The NFL Week 10 schedule is full of games that could shape the 2026 playoff race developing in both the AFC and NFC. The latest odds suggest several matchups are difficult to call, with experts divided on some of the biggest games on tap.
It will be another jam-packed week of important matchups, beginning with an NFC East showdown between the Washington Commanders and New York Giants on "Thursday Night Football." The action continues Sunday with several games carrying major postseason implications.
The Detroit Lions and New England Patriots kick off in the morning from Munich, Germany, and the early afternoon will then feature the Minnesota Vikings vs. Green Bay Packers in another crucial NFC North battle. The San Francisco 49ers and Dallas Cowboys
clash in the marquee late afternoon kickoff, while the Cincinnati Bengals and Pittsburgh Steelers meet again with first place in the AFC North on the line as a headliner for "Sunday Night Football."
Here's a look at expert picks, predictions and odds for every game on the NFL's Week 10 schedule.
NFL Week 10 game predictions and expert picks
Odds courtesy of BetMGM as of Tuesday, Nov. 10 at 12:30 p.m. ET.
Washington Commanders vs. New York Giants
- Date: Thursday, Nov. 12
- Time: 8:15 p.m. ET
- Location: Met Life Stadium (East Rutherford, New Jersey)
- TV: None
- Streaming: Prime Video, NFL+
- Spread: Giants (-2.5)
CBS Sports: Commanders 24, Giants 17
"The Commanders are actually playing decent football and if their coaching staff doesn't let them down, I think they have a good chance of winning. The Giants are beat up at quarterback, they're beat up at running back, and they're surviving by the skin of their teeth. Four of their five wins have come by one score. ... If the Commanders lose, their season is all but over, but if they win, they'll be right back in the NFC East race."
Sports Illustrated: Giants win and cover
"J.J. McCarthy has been surprisingly solid to begin his tenure with the Giants, ranking fifth in the NFL in completion percentage over expected (+5.3%) amongst quarterbacks who have played 60+ snaps this season. It's also no coincidence that over the last three weeks, the Giants have led the league in net yards per play at +1.5. Meanwhile, the Commanders continue to be a poorly coached team that doesn't thrive in any area, ranking in the bottom half of the NFL in virtually every metric."
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New England Patriots vs. Detroit Lions
- Date: Sunday, Nov. 15
- Time: 9:30 a.m. ET
- Location: FC Bayern Munich Stadium (Munich, Germany)
- TV: FOX
- Streaming: FOX One, Fubo, NFL+
- Spread: Lions (-3)
NFL Spin Zone: Lions 34, Patriots 20
"The Patriots have been exposed in two of their last three games against NFC North teams. Drake Maye has turned the ball over a ton this season, especially playing against some of the better-coached teams in the league. Playing in Germany, the Detroit Lions are going to look to hand the Patriots their fourth-straight NFC loss this season. The Detroit defense has picked things up considerably after a rough start to the season. Getting Brian Branch back has been massive for this team, but the absence of Jack Campbell definitely looms large as the season keeps rolling along."
CBS Sports: Lions 34, Patriots 27
"The Lions might put up 50 points. The good news for the Patriots is that even if the Lions do put up a 50-burger, New England might still keep up. Detroit has given up the MOST passing yards per game this year (260.9) ... The Patriots have faced six opponents this year with winning records, and in those games, Maye has thrown 11 interceptions to 9 touchdowns."
Kansas City Chiefs vs. Atlanta Falcons
- Date: Sunday, Nov. 15
- Time: 1 p.m. ET
- Location: Mercedes-Benz Stadium (Atlanta)
- TV: CBS
- Streaming: Paramount+, Fubo, NFL+
- Spread: Chiefs (-3.5)
Sporting News: Chiefs 28, Falcons 21
"The Falcons have lost four of their last five games, and they have allowed 373.8 yards per game in that stretch. That's going to make things easier for the Chiefs, who have dropped their last two road games. Patrick Mahomes has a 99.8 passer rating on the road. The Chiefs are 1-2 ATS when favored by less than seven points, so this is a tricky line."
Sports Betting Dime: Chiefs win and cover
"Kansas City leads Atlanta by five points per game (25.2 to 20.2) and more than 60 yards per game (384.1 to 322.7). The Chiefs also convert third downs at 41.7% versus 34.9% for the Falcons. Red-zone rates are nearly even, but Kansas City’s +3 turnover differential contrasts with Atlanta’s -8; Atlanta is also 3-6 against the spread."
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Minnesota Vikings vs. Green Bay Packers
- Date: Sunday, Nov. 15
- Time: 1 p.m. ET
- Location: Lambeau Field (Green Bay, Wisconsin)
- TV: FOX
- Streaming: FOX One, Fubo, NFL+
- Spread: Packers (-5.5)
CBS Sports: Packers 20, Vikings 17
"One downside for the Packers in this game is that they won't have Josh Jacobs, but that might not actually be a downside, since they didn't have him in Week 1 and Love still threw for nearly 400 yards. The Vikings started 6-0, but they're now in the reality check portion of their schedule: They're coming off back-to-back losses (Lions, Bills) and with the Packers and 49ers coming up, that losing streak could be at four in a row before Thanksgiving."
Sports Illustrated: Packers win and cover
"The Packers got off to a slow start to their season, but they're starting to pick up steam and now is the perfect time to buy in on them. Since Week 4, the Packers are fifth in EPA per play and third in opponent EPA per play. ... Matt LaFleur may know the secret to moving the ball against (the Vikings). Green Bay has scored 22+ points in five straight games against the Vikings, not including last year's Week 18 game in which the Packers started mostly backups."
Miami Dolphins vs. Indianapolis Colts
- Date: Sunday, Nov. 15
- Time: 1 p.m. ET
- Location: Lucas Oil Stadium (Indianapolis)
- TV: CBS
- Streaming: NFL Sunday Ticket (YouTube), Fubo
- Spread: Colts (-2.5)
Arizona Republic: Dolphins 21, Colts 17
"Malik Willis will give the Colts fits through the air and on the ground as the Dolphins upset Indianapolis and hand the Colts their sixth straight loss to help Miami move to 2-3 on the road."
Sports Betting Dime: Dolphins are the pick
“Indianapolis scores 20.4 points per game to Miami’s 15.5 and is more efficient in the red zone (58.3% to 47.6%). Miami’s counterarguments are its stronger third-down rate (41.6% to 36.9%) and a much better turnover differential (-2 versus -11). ... Although Indianapolis is 5-4 ATS to Miami’s 4-4 and remains a slight model favorite, a reduced spread and lower total make two and a half points valuable. Take Miami, not because its offense is better, but because the market has substantially repriced the matchup.”
Carolina Panthers vs. New Orleans Saints
- Date: Sunday, Nov. 15
- Time: 1 p.m. ET
- Location: Caesars Superdome (New Orleans)
- TV: FOX
- Streaming: NFL Sunday Ticket (YouTube), Fubo
- Spread: Saints (-1)
Sporting News: Saints 25, Panthers 22
"This is a toss-up in the NFC South. The Panthers have a minus-four turnover margin in their last three losses, and Bryce Young has taken 14 sacks in those games. New Orleans has not forced a turnover in their last four games. Tyler Shough has been efficient, and Audric Estime energized the running game in Week 9."
NFL Spin Zone: Saints 33, Panthers 31
"The Saints are favored by 1.5 points at home, which essentially means this game is viewed as a toss-up. Nobody knows where to plant their flag with either of these two teams right now, and that’s understandable. These teams know each other well, and the Panthers have one of the most banged-up defenses in the league."
Buffalo Bills vs. New York Jets
- Date: Sunday, Nov. 15
- Time: 1 p.m. ET
- Location: MetLife Stadium (East Rutherford, New Jersey)
- TV: CBS
- Streaming: NFL Sunday Ticket (YouTube), Fubo
- Spread: Bills (-8)
BetMGM: Bills win, but Jets cover
We’ve seen Buffalo in this spot once before. After escaping with an overtime win against the Rams on MNF, the mighty Bills traveled to face the Raiders as a 4.5-point favorite. Buffalo won the game 33-30, but the Raiders covered the spread thanks to a backdoor touchdown. ... New York ranks 16th in rush offense DVOA ahead of this game and 18th in total offensive DVOA. It should give them an advantage over Buffalo’s defense."
Sports Illustrated: Jets keep it close
"The Jets are far from a good team, but ... they're better than their record. They're 13th in net yards per play (+0.2), 19th in EPA per play, and 10th in success rate. Their secondary has been bad, but they rank 16th in opponent EPA per play, which could go a long way in keeping things tight against the Bills."
Houston Texans vs. Cleveland Browns
- Date: Sunday, Nov. 15
- Time: 1 p.m. ET
- Location: Huntington Bank Field (Cleveland)
- TV: FOX
- Streaming: NFL Sunday Ticket (YouTube), Fubo
- Spread: Texans (-4.5)
New York Post: Browns cover as underdogs
"The quarterback situation will be a question mark all season, but the pieces around that player, and the defense are the reason the Browns can compete. The Texans are coming off a huge blowout win over the Chargers in Los Angeles and are road favorites in this game, but their other true road games this season (excluding the NFL London Game) were a loss against the Colts in Week 3 and a win over the Titans in Week 5. That’s nobody’s idea of a gauntlet. The Browns seemed destined for a close finish every week and are 3-0 against the spread as home underdogs."
CBS Sports: Texans 24, Browns 16
"This genuinely does feel like a game that's going to boil down to Watson vs. the Texans. Watson has been sacked more times than any other QB in the NFL this year (33), and he'll be facing a defense that leads the NFL in sacks (29). That's a recipe for disaster."
Jacksonville Jaguars vs. Tennessee Titans
- Date: Sunday, Nov. 15
- Time: 1 p.m. ET
- Location: Nissan Stadium (Nashville, Tennessee)
- TV: FOX
- Streaming: NFL Sunday Ticket (YouTube), Fubo
- Spread: Jaguars (-10.5)
Sporting News: Jaguars 22, Titans 17
"Jacksonville is looking more like a Super Bowl contender behind a defense that allows just 15.1 points per game and has reinforcements. The Jaguars rank third in the NFL with 11 interceptions behind Jourdain Lewis with three and Travis Hunter with two. Those turnovers mean the difference against the Titans, who are coming off a bye week after three straight one-score games. Jacksonville outscored Tennessee 66-10 in two meetings last season."
NFL Spin Zone: Jaguars 37, Titans 20
"The talent gap is huge, the execution for the Jaguars has been outstanding in all phases, and they just added Jessie Bates, Jordan Davis, and Davon Godchaux leading up to the trade deadline. This team is absolutely all-in."
Los Angeles Rams vs. Arizona Cardinals
- Date: Sunday, Nov. 15
- Time: 4:05 p.m. ET
- Location: State Farm Stadium (Glendale, Arizona)
- TV: CBS
- Streaming: NFL Sunday Ticket (YouTube), Fubo
- Spread: Rams (-9.5)
Arizona Republic: Rams 27, Cardinals 19
"The Cardinals upset the Rams in Los Angeles earlier this season. You can bet LA remembers. There will be no Minshew Magic in this game as Arizona falls to 0-4 at home."
Sports Betting Dime: Cardinals cover the right number
"Los Angeles is clearly better on offense, averaging 23.8 points and 379.8 yards per game to Arizona’s 19.8 and 318.0; the Rams also convert 66.7% of red-zone trips to the Cardinals’ 42.9%. The teams’ against the spread records are closer (5-4 for Los Angeles, 4-5 for Arizona) ... Los Angeles is the likely winner, but does not mean a cover is equally likely. Arizona at home with more than a touchdown is the price-sensitive pick."
Seattle Seahawks vs. Las Vegas Raiders
- Date: Sunday, Nov. 15
- Time: 4:05 p.m. ET
- Location: Allegiant Stadium (Las Vegas)
- TV: CBS
- Streaming: NFL Sunday Ticket (YouTube), Fubo
- Spread: Seahawks (-3.5)
Sporting News: Seahawks 21, Raiders 18
"The Seahawks have quarterback injuries to Sam Darnold (hip), who is out and Drew Lock (oblique), who is the projected starter on the road. Las Vegas, however, is 1-3 at home and has lost five of its last six games. Veteran Kirk Cousins is coming off his worst start of the season. Fernando Mendoza is looming, but Seattle escapes with a much-needed road victory late."
NFL Spin Zone: Seahawks 22, Raiders 17
"Unless we see Lock and the Seattle offense turn the ball over 3 or more times (which is possible) in this game, this one should be another win for Seattle. The Raiders’ defense has struggled all year ... and they’re (not) going to have any answers for Jaxon Smith-Njigba. The Seahawks also finally have their backs healthy. Zach Charbonnet had 77 yards rushing to lead the team and Jadarian Price led the team with 54 yards receiving against Arizona."
San Francisco 49ers vs. Dallas Cowboys
- Date: Sunday, Nov. 15
- Time: 4:25 p.m. ET
- Location: AT&T Stadium (Arlington, Texas)
- TV: FOX
- Streaming: FOX One, Fubo, NFL+
- Spread: 49ers (-4)
ESPN: 49ers cover on the road
"Kyle Shanahan will have answers for both the run and pass game Sunday in Dallas. Schemed throws for Brock Purdy that create open coverage voids off play-action, plus a multiple run game with Christian McCaffrey and Kaelon Black to attack a Cowboys defense allowing 5.0 YPC (third most)."
BetMGM: Cowboys cover
"Dallas required overtime on Sunday in Indianapolis. But the underlying metrics suggested the Cowboys thoroughly dominated the Colts as a 4.5-point road favorite. The Cowboys outgained the Colts 508-271 and posted a 7.2-4.6 yards per play advantage. Two ill-timed Cowboys turnovers helped the Colts stay within striking distance. ... The Cowboys offer a stiff test for San Francisco’s defense, especially given the 49ers’ weakness at corner."
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Pittsburgh Steelers vs. Cincinnati Bengals
- Date: Sunday, Nov. 15
- Time: 8:20 p.m. ET
- Location: Paycor Stadium (Cincinnati)
- TV: NBC
- Streaming: Peacock, Fubo, NFL+
- Spread: Bengals (-3.5)
New York Post: Bengals win NFC North rematch
"Joe Burrow has been beyond impressive for the Bengals this season, leading the NFL in passing touchdowns (23) and passing yards per game (298.3). The Steelers defensive line has been awesome — Pittsburgh is tied for third in the NFL with 26 sacks — but Burrow has been good against the normal rush and the blitz so far this season. ... The Steelers average 22.5 points per game, but that number is buoyed by the fact that they attempt the second-most field goals in the league. The Steelers are near the bottom of the league in total touchdowns and red zone scores, while the Bengals defense is top-five in the red zone."
BetMGM: Steelers keep it close and cover
"Mike McCarthy’s offense averaged seven yards per play against Cincinnati. Recently, we’ve seen the Bengals defense struggle against inferior opponents. The unit allowed Tennessee to post its best offensive DVOA output of the entire season. The Bengals defense also struggles to defend opposing tight ends, a staple of Pittsburgh’s offense."
Los Angeles Chargers vs. Baltimore Ravens
- Date: Monday, Nov. 16
- Time: 8:15 p.m. ET
- Location: M&T Bank Stadium (Baltimore)
- TV: ESPN, ABC
- Streaming: ESPN Unlimited, Fubo, NFL+
- Spread: Ravens (-5)
Arizona Republic: Ravens 20, Chargers 14
"We keep thinking we are going to pick the Chargers to win, but we can't do it, especially with Justin Herbert's status for this game not known after hurting his hand in the loss to the Texans. Baltimore wins a very ugly game to end its four-game skid."
Sports Illustrated: Chargers finally win
"The Chargers' defense is just as good, if not better, than the Ravens. The two defenses are 16th and 17th in opponent EPA per play, and the Chargers are 18th in opponent success rate, while the Ravens are 22nd. Offensively ... the Chargers have been bad this season, but are we sure that Jacoby Brissett, an ineffective Derrick Henry, and a bad Ravens' receiving core are ready to outduel Justin Herbert and Co.?"
This article originally appeared on USA TODAY: NFL Week 10 game picks: Expert predictions, odds for every matchup
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