Defending Nations League champion Portugal hosts Wales at the Estádio José Alvalade on Thursday for a Group A opener.
The hosts fell to eventual champions Spain 1-0 in the round of 16 at the 2026 World Cup.
Jorge Jesus takes charge for the first time after replacing Roberto Martinez this summer. 41-year-old Cristiano Ronaldo remains in the squad and is set to start Thursday's match.
Watch Portugal vs. Wales on Fubo
Wales travels to Lisbon after a quiet summer due to missing out on the World Cup.
Craig Bellamy's side drew an incredibly difficult Nations League group with Norway and Denmark rounding out the quartet.
If you are looking for betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of OddsWire.
Portugal vs. Wales game odds
Portugal vs. Wales prediction, pick
Portugal's new era should get off to a fine start with a simple win over an inferior opponent at home.
Prediction: Portugal 2, Wales 0
Portugal vs. Wales channel, start time, streaming
- When: Thursday, September 24
- Where: Estádio José Alvalade (Lisbon, Portugal)
- Time: 2:45 p.m. ET
- Channel/streaming: Fox Soccer Plus (Watch LIVE on Fubo), ViX (Watch on Prime Video)
This article originally appeared on USA TODAY: Portugal vs. Wales Nations League prediction, start time, how to watch
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