By Marie Mannes, Niklas Pollard and Simon Johnson
STOCKHOLM, Oct 7 (Reuters) - Scientists Henri Kagan and Kenso Soai won the 2026 Nobel Prize in Chemistry for solving a long-standing riddle of asymmetric
"mirror image" molecules, a discovery hugely important for pharmaceutical manufacturing, the award-giving body said on Wednesday.
Soai, 76, is Japanese, and Kagan, 95, is French, and their work built on a discovery by the 19th century French chemist Louis Pasteur.
"This is the most exciting day in my life, I am very glad to share this prize with professor Henri Kagan," Soai said, speaking by phone to the Nobel Prize press conference, adding he had been out shopping when receiving the news.
The Nobel committee was still trying to contact Kagan to inform him of the award.
The chemistry Nobel, always the third prize to be awarded during Nobel week, followed those for medicine and physics announced on Monday and Tuesday.
'RIGHT-HANDED' AND 'LEFT-HANDED' MOLECULES
Many of the molecules essential to life exist in two forms that are mirror images of each other, like left and right hands. Yet living organisms almost exclusively use only one version, a phenomenon known as "homochirality" – from the Greek word for hand – that has puzzled chemists for more than a century.
This year's prize was awarded for discoveries that showed how chemical reactions can be driven to favour a single molecular mirror image, work that has been key for chemists who design reactions for the manufacture of pharmaceuticals.
"The left-handed version of the drug can have one effect, and the right-handed version can have another effect, and then we need methods for selectively preparing them," Peter Somfai, a member of the Nobel Committee for Chemistry, said.
"In developing such methods the findings of this year's laureates are important. They provided powerful tools for that," he said.
BUILDING ON WORK BY LOUIS PASTEUR
The first link in the chain in solving the problem was work by Pasteur, who died before the Nobel Prizes were first awarded.
He was looking at tartaric acid, important in the production of wine, and noticed that bacteria only ferment one of the two forms of tartaric acid – that which is naturally found in grapes. With the other there is no fermentation.
That proved that some substances occur in two forms and that they have different properties, sometimes very damaging to health.
How to create the right form of a chiral substance was a problem not solved until Kagan and Soai were able to produce asymmetric reactions, creating an excess of one form.
The importance of the work is illustrated by the case of the thalidomide scandal in the early 1960s, when thousands of children were affected by birth defects caused by a sedative, thalidomide.
When researchers analysed what had happened, they realised that it was the active substance's mirror image that caused the harm.
PRIZES ESTABLISHED IN WILL OF SWEDISH INVENTOR
Established in the will of Swedish inventor and businessman Alfred Nobel, the prizes for achievements in science, literature and peace have been awarded since 1901, with a few interruptions mostly due to the world wars.
Nobel, a chemist by trade, amassed huge wealth in the 19th century from inventions primarily tied to warfare, most notably dynamite. The economics prize is a later addition funded by the Swedish central bank.
Sometimes overshadowed by more famous laureates in the fields of physics, literature and peace, the chemistry awards have still recognised many influential discoveries such as nuclear fission and genetic sequencing techniques.
Last year's chemistry award went to scientists Susumu Kitagawa, Richard Robson and Omar Yaghi for the development of so-called metal–organic frameworks, molecular constructions that can help tackle challenges such as climate change and lack of fresh water.
The laureates will receive their medals from Sweden's King Carl XVI Gustaf at a ceremony in Stockholm on December 10, the anniversary of Alfred Nobel's death. The awards are followed by a lavish banquet at Stockholm City Hall.
They also share 12 million Swedish crowns ($1.2 million), as well as the fame of winning arguably the world's most prestigious science award.
The peace prize, the only Nobel not presented in Sweden, is awarded separately in Oslo.
($1 = 10.0309 Swedish crowns)
(Reporting by Johan Ahlander, Niklas Pollard, and Marie Mannes in Stockholm; additional reporting by Simon Johnson, Greta Rosen Fondahn and Anna Ringstrom in Stockholm, Terje Solsvik in Oslo and Nobuhiro Kubo in Tokyo; Editing by Alex Richardson and Toby Chopra)
