The Iowa State Cyclones and BYU Cougars play on Friday, Oct. 9, 2026, at LaVell Edwards Stadium in Provo, Utah, in a game on the college football Week 6 schedule.
Which team will win the college football Week 6 game?
Check out these college football Week 6 picks and college football Week 6 predictions for the game, which can be seen at 7:15 p.m. MST on ESPN (stream with FUBO).
BYU is a 10.5-point favorite over Iowa State in college football Week 6 odds for the game, according to BetMGM Sportsbook.
The Cougars are -450 on the moneyline, while the Cyclones are +340. The over/under (point total) for the game is set at 48.5 points.
Watch Iowa State vs BYU on FUBO (free trial)
The Arizona Republic: BYU 31, Iowa State 17
Jeremy Cluff writes: "The Cougars struggled in a 17-10 win over TCU on the road.
Bear Bachmeier and BYU will get rolling again at home against the Cyclones to move to 5-0 on the season."
Bookies.com: Bet the under in BYU vs Iowa State game
Bill Speros writes: "Our model has BYU winning by 15.2 points against a 14.5-point line, so there's slight value on the Cougars — but the total is where we want to be. The issues for the defense-driven Cyclones spin around BYU's ground game and the altitude in Provo. Defense travels, but it tires at altitude. Still, the Cougars will likely pull the starters if this one gets out of hand, given next week's Holy War against Notre Dame. Two run-centric game plans and ISU's defense combine to keep this one under the total."
Dimers.com: BYU 31, Iowa State 19
It writes: "The numbers give Iowa State a win probability of 17.2%, while Brigham Young has a win probability of 82.8%."
ESPN: BYU has an 83.8% chance to defeat Iowa State
The site gives the Cyclones a 16.2% shot at winning the college football Week 6 game.
Sports Betting Dime: BYU 29.1, Iowa State 21.7
The site's formula predicts that the Cougars will beat the Cyclones in the Week 6 college football game.
Sporting News: BYU 29, Iowa State 17
Bill Bender writes: "The Cougars are double-digit home favorites against the Cyclones, who averaged 15 points per game in road losses to Iowa and Utah this season. BYU running back LJ Martin suffered a lower body injury in Week 5 – and his status will need to be monitored throughout the week. BYU is 3-0 ATS against Power 4 opponents this season."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Iowa State vs BYU picks, predictions, odds for Big 12 football Week 6
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