The Iowa State Cyclones and Iowa Hawkeyes play on Saturday, Sept. 12, 2026, at Kinnick Stadium in Iowa City, Iowa, in a game on the college football Week 2 schedule.
Which team will win the college football Week 2 game?
Check out these college football Week 2 picks and college football Week 2 predictions for the game, which can be seen at 4:30 p.m. MST on NBC (stream with Peacock).
Iowa is a 14.5-point favorite over Iowa State in college football Week 2 odds for the game, according to BetMGM Sportsbook.
The Hawkeyes are -625 on the moneyline, while the Cyclones are +475. The over/under (point total) for the game is set at 41.5 points.
Watch Iowa State vs Iowa on Peacock
The Arizona Republic: Iowa 24, Iowa State 20
Jeremy Cluff writes: "The Hawkeyes are more than a two-touchdown favorite over
the Cyclones, but you never know what might happen in this rivalry game. We have a pretty good idea that Iowa's defense will help it secure a win, however."
Bookies.com: Bet the under in Iowa vs Iowa State game
Bill Speros writes: "Our 'Ride Or Die' pick of the College Football Season each year is the under whenever Iowa and Iowa State vie for the Cy-Hawk Trophy. This time, Matt Campbell isn’t around to make it close."
Dimers.com: Iowa 29, Iowa State 15
It writes: "After extensive simulations, our model gives Iowa State a win probability of 14%, while Iowa has a win probability of 86%."
ESPN: Iowa has an 84.5% chance to defeat Iowa State on Saturday
The site gives the Cyclones a 15.4% shot at winning the college football Week 2 game.
Sports Betting Dime: Iowa 23.5, Iowa State 20.2
The site's formula predicts that the Hawkeyes will beat the Cyclones in the Week 2 college football game.
Des Moines Register: Iowa 28, Iowa State 7
Travis Hines writes: "This is not a very good setup for Iowa State against a top-25 rival on the road. This will be the biggest game and toughest environment for nearly the entire roster. Sometimes the intangible can trump the tale of the tape in rivalry games, but the matchup here isn’t friendly for the Cyclones."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Iowa State vs Iowa picks, predictions, odds for Week 2 game Saturday
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