Lions vs Bills odds, point spread, moneyline, total for game Thursday

Who is favored in the NFL Week 2 odds between the Detroit Lions and Buffalo Bills on Thursday, Sept. 17? Here's what you need to know about NFL Week 2 Thursday Night Football game odds between the Bills and Lions, which is being played at the Bills' Highmark Stadium at 5:15 p.m. MST (8:15 p.m. ET) a

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Who is favored in the NFL Week 2 odds between the Detroit Lions and Buffalo Bills on Thursday, Sept. 17?

Here's what you need to know about NFL Week 2 Thursday Night Football game odds between the Bills and Lions, which is being played at the Bills' Highmark Stadium at 5:15 p.m. MST (8:15 p.m. ET) and can be seen on Amazon Prime (stream with Prime Video).

What is the point spread for the Lions vs Bills game in NFL Week 2?

What is the moneyline for the Bills vs Lions game on Thursday?

What is the over/under (point total) for the Detroit vs Buffalo game on Sept. 17?

Watch Lions vs Bills game on Amazon Prime Video

Lions vs Bills odds: What is the point spread Thursday?

According to BetMGM Sportsbook, the Bills are a 4.5-point favorite over the Lions

in the NFL Week 2 game on Sept. 17.

Bills vs Lions odds: What is the moneyline on Sept. 17?

BetMGM Sportsbook lists Buffalo as -225 on the moneyline for the NFL Week 2 game on Thursday. It has Detroit at +185.

Lions vs Bills odds: What is the over/under in NFL Week 2 game?

The point total for the Bills vs Lions Week 2 NFL game this week is listed at 54 points, per BetMGM Sportsbook.

Detroit Lions players celebrate a tackle for loss in the second quarter of a game against the New Orleans Saints at Ford Field in Detroit on Sunday Sept. 13, 2026.

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Lions vs Bills odds, point spread, moneyline, total for game Thursday

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