Texans vs Bills predictions, picks, odds for NFL Week 1 game Sunday

Who will win the Houston Texans vs Buffalo Bills NFL Week 1 game? The Buffalo Bills and Houston Texans play on Sunday, Sept. 13, at the Texans' NRG Stadium in a game on the NFL Week 1 schedule. What do NFL Week 1 odds say about the game? Who are NFL Week 1 predictions and NFL Week 1 picks taking in

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Who will win the Houston Texans vs Buffalo Bills NFL Week 1 game?

The Buffalo Bills and Houston Texans play on Sunday, Sept. 13, at the Texans' NRG Stadium in a game on the NFL Week 1 schedule.

What do NFL Week 1 odds say about the game? Who are NFL Week 1 predictions and NFL Week 1 picks taking in the game?

Which team has the best chance to win the game according to NFL Week 1 win probabilities?

Check out The Arizona Republic's score prediction for the game, as well as Bills vs Texans picks, odds and win chances for the NFL Week 1 game, which can be seen at 10 a.m. MST on CBS (stream with FUBO).

Watch Bills at Texans on FUBO (free trial)

Houston Texans vs Buffalo Bills prediction

The Arizona Republic predicts a 23-20 win for the Bills over the Texans in the NFL Week 1 game.

Jeremy Cluff writes: "Could this be the game of the week? It had the smallest point spread in early odds, with the Bills favored by a point on the road at Houston. Josh Allen will deliver late."

Buffalo Bills vs Houston Texans picks

Will the Texans or Bills win the game in NFL Week 1?

Bookies.com says to bet the Texans on the moneyline vs. the Bills.

Sports Betting Dime's formula predicts a 19.2-19.1 win for the Bills over the Texans.

Dimers.com's final score prediction? Bills 23, Texans 21.

BetMGM is taking the Texans on the moneyline against the Bills.

Houston Texans vs Buffalo Bills win probabilities

The Bills have a 53.5% chance to beat the Texans, according to ESPN.

The site gives Texans a 46.1% shot at winning the NFL Week 1 game, with the remaining percentage accounting for a tie.

Buffalo Bills vs Houston Texans odds

The Bills are a 1-point favorite over the Texans in NFL Week 1 odds for the game, courtesy of BetMGM Sportsbook.

Buffalo is -118 on the moneyline, while Houston is -102.

The over/under (point total) is set at 44.5 points.

Josh Allen #17 of the Buffalo Bills arrives at Highmark Stadium before the game against the New York Jets on January 04, 2026 in Orchard Park, New York.

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Texans vs Bills predictions, picks, odds for NFL Week 1 game Sunday

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