The Big 12 football Week 2 schedule has some intriguing games, with some very intriguing betting lines.
What do college football betting odds say about each Big 12 game this week, Week 2 of the 2026 regular season?
Who is favored in the Arizona State vs Texas A&M game? Who is the favorite in the Iowa State vs Iowa game?
What do the odds say about Missouri vs Kansas, Oregon at Oklahoma State, Arizona at BYU and the other Big 12 college football games in Week 2?
Take a look at the point spread, moneyline and over/under for every game on the Week 2 Big 12 college football schedule, courtesy of BetMGM Sportsbook.
Big 12 football odds: Week 2 point spreads
- Missouri (-6) at Kansas (+6)
- Oregon (-22.5) at Oklahoma State (+22.5)
- Arizona State (+14.5) at Texas A&M (-14.5)
- Washington State (+17.5) at Kansas State (-17.5)
- UT Martin (N/A) at West Virginia (N/A)
- Arizona (+7.5) at BYU (-7.5)
- Weber State (+34.5) at Colorado (-34.5)
- UCF (+7.5) at Pittsburgh (-7.5)
- Southern (+50.5) at Houston (-50.5)
- Western Carolina (+36.5) at Cincinnati (-36.5)
- Texas Tech (-26) at Oregon State (+26)
- Iowa State (+14.5) at Iowa (-14.5)
- Prairie View A&M (+38.5) at Baylor (-38.5)
- Grambling (+44.5) at TCU (-44.5)
- Arkansas (+12) at Utah (-12)
Big 12 football odds: Week 2 moneylines
- Missouri (-235) at Kansas (+190)
- Oregon (-2000) at Oklahoma State (+1150)
- Arizona State (+500) at Texas A&M (-650)
- Washington State (+825) at Kansas State (-1200)
- UT Martin (N/A) at West Virginia (N/A)
- Arizona (+240) at BYU (-295)
- Weber State (+2500) at Colorado (-10000)
- UCF (+250) at Pittsburgh (-300)
- Southern (+8000) at Houston (N/A)
- Western Carolina (+2400) at Cincinnati (N/A)
- Texas Tech (-3000) at Oregon State (+1700)
- Iowa State (+475) at Iowa (-625)
- Prairie View A&M (+8000) at Baylor (N/A)
- Grambling (+8000) at TCU (N/A)
- Arkansas (+400) at Utah (-500)
Big 12 football odds: Week 2 over/unders (point totals)
- Missouri at Kansas: 50.5
- Oregon at Oklahoma State: 57.5
- Arizona State at Texas A&M: 51.5
- Washington State at Kansas State: 50.5
- UT Martin at West Virginia: N/A
- Arizona at BYU: 50.5
- Weber State at Colorado: 52.5
- UCF at Pittsburgh: 57.5
- Southern at Houston: 60.5
- Western Carolina at Cincinnati: 60.5
- Texas Tech at Oregon State: 51.5
- Iowa State at Iowa: 41.5
- Prairie View A&M at Baylor: 54.5
- Grambling at TCU: 54.5
- Arkansas at Utah: 56.5
Reach
Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Big 12 football Week 2 odds, point spreads, moneylines, over/unders
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