The Colorado Buffaloes and Baylor Bears play on Saturday, Sept. 26, 2026, at McLane Stadium in Waco, Texas, in a game on the college football Week 4 schedule.
Which team will win the college football Week 4 game?
Check out these college football Week 4 picks and college football Week 4 predictions for the game, which can be seen at 9 a.m. MST on ESPN2 (stream with FUBO).
Baylor is a 10-point favorite over Colorado in college football Week 4 odds for the game, according to BetMGM Sportsbook.
The Bears are -375 on the moneyline, while the Buffaloes are +300. The over/under (point total) for the game is set at 55.5 points.
Watch Colorado vs Baylor on FUBO (free trial)
The Arizona Republic: Baylor 31, Colorado 17
Jeremy Cluff writes: "The Buffaloes were humbled in a 41-7 loss at Northwestern. This
game won't be quite so bad, but it will end with a second straight loss for Deion Sanders and company."
Bookies.com: Bet the under in Baylor vs Colorado game
Bill Speros writes: "The Buffs got socked in the snout Saturday night 41-7 by Northwestern. They get no quarter this week in the Big 12. Both QBs – Baylor’s Nate Bennett and Colorado’s Julian Lewis – each have 6 TD passes against just 2 picks. Bennett backed up D.J. Langway, who got hurt in Week 1. This game has an 11 a.m. local time kick in Waco. Baylor’s defense should be able to contain Colorado, which showed its true colors in Evanston. Lean into the under."
Dimers.com: Baylor 33, Colorado 22
It writes: "After extensive simulations, our model gives Colorado a win probability of 20%, while Baylor has a win probability of 80%."
ESPN: Baylor has an 80.3% chance to defeat Colorado
The site gives the Buffaloes a 19.7% shot at winning the college football Week 4 game.
Sports Betting Dime: Baylor 26.8, Colorado 16.1
The site's formula predicts that the Bears will beat the Buffaloes in the Week 4 college football game.
Yahoo Sports: Bet the over in Baylor vs Colorado game
Corbie Craig writes: "Colorado's offense isn't as bad as seven points looks, either. Julian Lewis has 658 yards and six touchdowns, and the Buffaloes put 52 on Weber State two weeks ago. If this spread is anywhere close to right, Colorado is going to be throwing from behind for most of the afternoon, and Baylor's tempo means there will be plenty of possessions to do it with. We make this total 57.6. The last time these two played, in 2024, it took a Hail Mary and overtime to settle it at 38-31."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Colorado vs Baylor picks, predictions, odds for Big 12 football Week 4
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