The Utah Utes and Iowa State Cyclones play on Saturday, Sept. 26, 2026, at Jack Trice Stadium in Ames, Iowa, in a game on the college football Week 4 schedule.
Which team will win the college football Week 4 game?
Check out these college football Week 4 picks and college football Week 4 predictions for the game, which can be seen at 12:30 p.m. MST on FOX (stream with FUBO).
Utah is an 8-point favorite over Iowa State in college football Week 4 odds for the game, according to BetMGM Sportsbook.
The Utes are -350 on the moneyline, while the Cyclones are +275. The over/under (point total) for the game is set at 48.5 points.
Watch Utah vs Iowa State on FUBO (free trial)
The Arizona Republic: Utah 27, Iowa State 20
Jeremy Cluff writes: "Devon Dampier and the Utes have their eyes on a Big 12 title
and a favorable schedule for the next few weeks. Utah won't slip up here."
Bookies.com: Bet the under in Iowa State vs Utah game
Bill Speros writes: "The Utes have won their first three games by a combined score of 142-24. Kyle Who? Things get a bit more challenging this week in Ames as both teams begin their Big 12 schedules. Iowa State and the under at home is one of the most natural plays in all of college football. The Cyclones stifle defenses in and out of the conference inside Jack Trice Stadium. Utah looks to run and control the line of scrimmage and the clock. That suits us just fine."
Dimers.com: Utah 29, Iowa State 21
It writes: "After extensive simulations, our model gives Utah a win probability of 75%, while Iowa State has a win probability of 25%."
ESPN: Utah has a 75.8% chance to defeat Iowa State
The site gives the Cyclones a 24.1% shot at winning the college football Week 4 game.
Sports Betting Dime: Utah 28, Iowa State 20.1
The site's formula predicts that the Utes will beat the Cyclones in the Week 4 college football game.
Des Moines Register: Utah 21, Iowa State 17
It writes: "The Cyclones' defense keeps them in the game and Iowa State gives the Utes a good battle. The Cyclones build more positive momentum heading into an Oct. 3 home game against West Virginia."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
Support local journalism: Subscribe to azcentral.com today. Sign up for azcentral Preps Now. And be sure to subscribe to our daily sports newsletters so you don't miss a thing.
This article originally appeared on Arizona Republic: Utah vs Iowa State picks, predictions, odds for Big 12 football Week 4
Advertiser disclosure: USA TODAY may earn a commission when you sign up through links on this page. Commissions never influence our editorial coverage or rankings. Offers and odds were accurate at publication and are subject to change; terms apply — see the operator’s site. This is general information, not betting, legal or financial advice. To the fullest extent permitted by law, USA TODAY is not liable for losses arising from your use of it.
Must be 21+ (18+ where permitted). Sports betting and casino gaming are not legal everywhere; complying with the laws where you are located is your responsibility. Gamble only with funds you can afford to lose. Gambling problem? Help is available 24/7 — call or text 1-800-GAMBLER, or call the National Problem Gambling Helpline at 1-800-MY-RESET. State helplines and responsible gaming resources.
