The West Virginia Mountaineers and Iowa State Cyclones play on Saturday, Oct. 3, 2026, at Jack Trice Stadium in Ames, Iowa, in a game on the college football Week 5 schedule.
Which team will win the college football Week 5 game?
Check out these college football Week 5 picks and college football Week 5 predictions for the game, which can be seen at 9 a.m. MST on TNT (stream with Sling).
Iowa State is a 3.5-point favorite over West Virginia in college football Week 5 odds for the game, according to BetMGM Sportsbook.
The Cyclones are -160 on the moneyline, while the Mountaineers are +130. The over/under (point total) for the game is set at 52.5 points.
Watch West Virginia vs Iowa State on Sling
The Arizona Republic: West Virginia 28, Iowa State 20
Jeremy Cluff writes: "The loser of this game falls to 0-2
in conference play. The Mountaineers may be the underdog, but we see Rich Rodriguez's offense doing enough to upset the Cyclones."
Bookies.com: Bet Iowa State on the moneyline vs West Virginia
Bill Speros writes: "Football fans across Iowa will be losing their mid-morning buzz around halftime. Both Iowa and Iowa State have 11 a.m. local kicks. The Cyclones trailed Utah by 21 at the half Saturday and lacked enough octane and oxygen to pull off a comeback. Expect a much better start here, where ISU produces a grinding, low-variance game behind a stout defense. West Virginia will look to run the ball and eat clock to keep it close. Our model has Iowa State by 4.4 — solid value at this price."
Dimers.com: Iowa State 28, West Virginia 25
It writes: "After extensive simulations, our model gives West Virginia a win probability of 41%, while Iowa State has a win probability of 59%."
ESPN: Iowa State has a 62.3% chance to defeat West Virginia
The site gives the Mountaineers a 37.7% shot at winning the college football Week 5 game.
Sports Betting Dime: Iowa State 26.6, West Virginia 24.8
The site's formula predicts that the Cyclones will beat the Mountaineers in the Week 5 college football game.
Des Moines Register: Iowa State 31, West Virginia 21
It writes: "The Cyclones cover the spread and notch their first Big 12 victory before heading to BYU on Friday, Oct. 9."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: West Virginia vs Iowa State picks, predictions, odds for Week 5 game
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