Who will win on Thursday Night Football in NFL Week 1?
The San Francisco 49ers and Los Angeles Rams play on Thursday, Sept. 10, in Melbourne, Australia, in a game on the NFL Week 1 schedule.
What do NFL Week 1 odds say about the Thursday Night Football game? Who are NFL Week 1 predictions and NFL Week 1 picks taking in the game?
Which team has the best chance to win the game according to NFL Week 1 win probabilities
?Check out The Arizona Republic's score prediction for the Thursday Night Football game, as well as 49ers vs Rams picks, odds and win chances for the NFL Week 1 game, which can be seen at 5:35 p.m. MST on Netflix.
NFL Week 1 picks: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals | Saints vs Lions | Bills
vs Texans | Ravens vs Colts | Browns vs Jaguars | Falcons vs Steelers | Jets vs Titans | Cardinals vs Chargers | Dolphins vs Raiders | Packers vs Vikings | Commanders vs Eagles | Cowboys vs Giants | Broncos vs Chiefs | The Republic's predictions
Thursday Night Football prediction for Rams vs 49ers game
The Arizona Republic is predicting a 27-23 win for the Rams over the 49ers in the NFL Week 1 Thursday Night Football game.
Jeremy Cluff writes: "The Rams are the favorite to win the Super Bowl and could have an elite defense with Aaron Donald and Myles Garrett. The defense will make a big play or two to seal a big NFC West win in Week 1 against San Francisco."
Thursday Night Football picks for 49ers vs Rams game
Will the Rams or 49ers win the Thursday Night Football game in NFL Week 1?
Bookies.com says to bet the 49ers with the points against the Rams.
Sports Betting Dime's formula predicts a 29.4-21.7 win for the Rams over the 49ers.
Dimers.com's final score prediction? Rams 26, 49ers 23
BetMGM is predicting that the 49ers will score under 21.5 points against the Rams.
Thursday Night Football win probabilities for Rams vs 49ers game
The Rams have a 60.5% chance to beat the 49ers on Thursday Night Football, according to ESPN.
The site gives the 49ers a 39.2% shot at winning the NFL Week 1 game, with the remaining percentage accounting for a tie.
Thursday Night Football odds for 49ers vs Rams game
The Rams are a 3.5-point favorite over the 49ers in NFL Week 1 odds for the game, courtesy of BetMGM Sportsbook.
Los Angeles is -200 on the moneyline, while San Francisco is +165.
The over/under (point total) is set at 48.5 points.
NFL Week 1 odds: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals | Saints vs Lions | Bills vs Texans | Ravens vs Colts | Browns vs Jaguars | Falcons vs Steelers | Jets vs Titans | Cardinals vs Chargers | Dolphins vs Raiders | Packers vs Vikings | Commanders vs Eagles | Cowboys vs Giants | Broncos vs Chiefs | Point spreads, moneylines, over/unders
NFL's highest paid players in 2026: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Overall | By position | By team
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Thursday Night Football predictions, picks, odds for Rams vs 49ers
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