The Arizona Cardinals face the San Francisco 49ers in a game on the NFL Week 3 schedule on Sunday, Sept. 27, 2026.
The Cardinals are 1-1 on the season, coming off a 31-7 loss to the Seattle Seahawks in NFL Week 2.
The 49ers are 2-0 after beating the Miami Dolphins last week, 35-13.
What's the Arizona vs San Francisco Week 3 NFL game score?
Follow our live updates for highlights, news, notes and analysis from the NFL game today at Levi's Stadium in Santa Clara, California. Refresh this page for the latest score and information from the NFL Sunday matchup.
Watch Cardinals vs 49ers game on FUBO (free trial)
What time is the Cardinals vs 49ers game today?
The San Francisco 49ers vs Arizona Cardinals Week 3 NFL game is scheduled for 1:05 p.m. MST (4:05 p.m. ET) on Sunday, Sept. 27, 2026.
NFL Week 3 schedule:
Chargers at Bills | Panthers at Browns | Jets at Lions | Texans at Colts | Patriots at Jaguars | Chiefs at Dolphins | Titans at Giants | Bengals at Steelers | Seahawks at Commanders | Cardinals at 49ers | Vikings at Buccaneers | Raiders at Saints | Ravens vs Cowboys | Rams at Broncos | TV channels | Announcers | How to watch
What channel is the 49ers vs Cardinals game on Sunday?
The Arizona Cardinals vs San Francisco 49ers NFL Week 3 game today can be seen on TV on FOX.
How can I stream the Cardinals vs 49ers game on Sept. 27?
The San Francisco vs Arizona game in NFL Week 3 can be streamed on FUBO, which offers a free trial.
Click here to sign up for a free trial of FUBO
Who is announcing the 49ers vs Cardinals NFL Week 3 game?
Kevin Kugler will have the play-by-play call of the Week 3 NFL game between the Arizona Cardinals and San Francisco 49ers today, with Daryl Johnston as the analyst.
San Francisco 49ers vs Arizona Cardinals prediction
The Arizona Republic is predicting a 31-17 win for the 49ers over the Cardinals in the NFL Week 3 Sunday football game.
Jeremy Cluff writes: "The Cardinals fell back to Earth in their Week 2 loss to the Seahawks. We have a feeling more humble pie is coming. Brock Purdy and San Francisco have looked really good through two weeks."
NFL Week 3 predictions: Chargers at Bills | Panthers at Browns | Jets at Lions | Texans at Colts | Patriots at Jaguars | Chiefs at Dolphins | Titans at Giants | Bengals at Steelers | Seahawks at Commanders | Cardinals at 49ers | Vikings at Buccaneers | Raiders at Saints | Ravens vs Cowboys | Rams at Broncos | Eagles at Bears | Win probabilities
Arizona Cardinals vs San Francisco 49ers picks
Will the 49ers or Cardinals win the game in NFL Week 3?
Bookies.com says to bet the 49ers to cover against the Cardinals.
Sports Betting Dime's formula predicts a 17.2-13 win for the 49ers over the Cardinals.
Dimers.com's final score prediction? 49ers 28, Cardinals 19.
Sportnaut is predicting a 35-24 win for the 49ers over the Cardinals.
San Francisco 49ers vs Arizona Cardinals win probabilities
The 49ers have a 90.3% chance to beat the Cardinals, according to ESPN.
The site gives the Cardinals a 9.6% shot at winning the NFL Week 3 game, with the remaining percentage accounting for a tie.
NFL Week 3 picks: Falcons at Packers | Chargers at Bills | Panthers at Browns | Jets at Lions | Texans at Colts | Patriots at Jaguars | Chiefs at Dolphins | Titans at Giants | Bengals at Steelers | Seahawks at Commanders | Cardinals at 49ers | Vikings at Buccaneers | Raiders at Saints | Ravens vs Cowboys | Rams at Broncos | Eagles at Bears | The Republic's predictions
Cardinals vs 49ers odds: What is the point spread Sunday?
According to BetMGM Sportsbook, the 49ers are an 8.5-point favorite over the Cardinals in the NFL Week 3 game on Sept. 27.
49ers vs Cardinals odds: What is the moneyline on Sept. 27?
BetMGM Sportsbook lists San Francisco as -450 on the moneyline for the NFL Week 3 game on Sunday. It has Arizona at +340.
Cardinals vs 49ers odds: What is the over/under in NFL Week 3 game?
The point total for the 49ers vs Cardinals Week 3 NFL game this week is listed at 48 points, per BetMGM Sportsbook.
NFL Week 3 odds: Falcons at Packers | Chargers at Bills | Panthers at Browns | Jets at Lions | Texans at Colts | Patriots at Jaguars | Chiefs at Dolphins | Titans at Giants | Bengals at Steelers | Seahawks at Commanders | Cardinals at 49ers | Vikings at Buccaneers | Raiders at Saints | Ravens vs Cowboys | Rams at Broncos | Eagles at Bears | Point spreads, moneylines, totals for betting
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This article originally appeared on Arizona Republic: Cardinals vs 49ers live score updates from NFL Week 3 game today
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