The Buffalo Bills and Los Angeles Rams play on Monday, Oct. 12, at the Rams' SoFi Stadium in a game on the NFL Week 5 schedule.
Which team will win the NFL Week 5 Monday Night Football game?
Check out these NFL Week 5 picks and NFL Week 5 predictions for the game, which can be seen at 5:15 p.m. MST on ESPN and ABC (stream with FUBO).
The Rams are a 2.5-point favorite over the Bills in NFL Week 5 odds for the game, courtesy of BetMGM Sportsbook.
Los Angeles is -150 on the moneyline, while Buffalo is +125. The over/under (point total) is set at 54.5 points.
NFL Week 5 picks: Buccaneers vs Cowboys | Eagles vs Jaguars | Bengals vs Dolphins | Raiders vs Patriots | Vikings vs Saints | Browns vs Jets | Colts vs Steelers | Texans vs Titans | Giants vs Commanders
| Bears vs Packers | Broncos vs Chargers | Lions vs Cardinals | 49ers vs Seahawks | Ravens vs Falcons | Bills vs Rams | The Republic's predictions
Watch Bills vs Rams on FUBO (free trial)
The Arizona Republic: Rams 30, Bills 27
Jeremy Cluff writes: "The Rams appeared to get on track late in their comeback win over the Eagles in Week 4. Can they stay on that track? Yes, Matthew Stafford and company can, and will, with a close win over Josh Allen and the Buffalo Bills in NFL Week 5."
Bookies.com: Bet the over in Rams vs Bills game
Bill Speros writes: "The Rams and Bills remain the betting favorites to win the Super Bowl. The Rams (2-2, 2-2 ATS) have seen their defense hobbled without the injured Myles Garrett. Although Garrett wasn't missed as the Rame beat the Eagles 24-20 at Philly Sunday, rallying from a 10-point deficit. The Bills defense got exposed by Drake Maye, who engineered the second 4th-quarter comeback of his career in Buffalo's 29-26 loss. That formula lines up perfectly for Stafford & Company. Look for a nifty, high-scoring Monday night track meet inside SoFi Stadium."
Sports Betting Dime: Bills 27.4, Rams 23.9
The site's formula predicts that the Bills will win the NFL Week 5 game against the Rams.
ESPN: Rams have a 59.3% chance to beat Bills
The site gives the Bills a 40.3% shot at winning the NFL Week 5 game, with the remaining percentage accounting for a tie.
Dimers: Rams 28, Bills 25
It writes: "The numbers give the Bills a win probability of 39.4%, while the Rams have a win probability of 60.6%."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Bills vs Rams picks, predictions, odds for NFL Week 5 game Monday
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