The Indianapolis Colts and Kansas City Chiefs play on Sunday, Sept. 20, at the Chiefs' Arrowhead Stadium in a game on the NFL Week 2 schedule.
Which team will win the NFL Week 2 Sunday Night Football game?
Check out these NFL Week 2 picks and NFL Week 2 predictions for the game, which can be seem at 5:20 p.m. MST on NBC (stream with Peacock).
The Chiefs are a 6.5-point favorite over the Colts in NFL Week 2 odds for the game, courtesy of BetMGM Sportsbook.
Kansas City is -300 on the moneyline, while Indianapolis is +240. The over/under (point total) is set at 48 points.
NFL Week 2 picks: Lions vs Bills | Panthers vs Falcons | Saints vs Ravens | Vikings vs Bears | Bengals vs Texans | Steelers vs Patriots | Packers vs Jets | Browns vs Buccaneers | Eagles
vs Titans | Jaguars vs Broncos | Raiders vs Chargers | Seahawks vs Cardinals | Commanders vs Cowboys | Dolphins vs 49ers | Colts vs Chiefs | Giants vs Rams | The Republic's predictions
Watch Colts vs Chiefs on Peacock
The Arizona Republic: Chiefs 27, Colts 20
Jeremy Cluff writes: "The Chiefs will be on a short week for this game after playing on Monday Night Football in NFL Week 1. It won't matter."
Bookies.com: Bet the Chiefs to cover vs Colts
Bill Speros writes: "Taylor, Travis and Patrick opened their season Monday night against the Denver Broncos. Indianapolis, meanwhile, had no answers on defense for Lamar Jackson, Derrick Henry and the Ravens Sunday. The Colts won't be able to crack the code when it comes to stoppng a healthy Patrick Mahomes at Arrowhead, either. Offensively, Daniel Jones remains Daniel Jones until further notice. Jonathan Taylor can’t carry this team by himself. Lock this one in before it moves north of touchdown."
Sports Betting Dime: Colts 21, Chiefs 20.8
The site's formula predicts that the Colts will win the NFL Week 2 game against the Chiefs.
ESPN: Chiefs have a 69.7% chance to beat Colts
The site gives the Colts a 30.1% shot at winning the NFL Week 2 game, with the remaining percentage accounting for a tie.
Dimers: Chiefs 26, Colts 20
It writes: "The numbers give the Colts a win probability of 30.0%, while the Chiefs have a win probability of 70.0%."
Sportsnaut: Chiefs 28, Colts 21
Matt Johnson writes: "The Kansas City Chiefs finally have a running back who can take advantage of bad run defenses, which the Indianapolis Colts certainly appeared to have in Week 1. Patrick Mahomes and Andy Reid also have to be feeling good about what Rashee Rice could do against a defense that got torched by Zay Flowers in just three quarters. Kansas City already has the advantage offensively, and if its defensive line can generate some consistent pressure on Daniel Jones, he will make a turnover-worthy throw that could get picked off and put the Chiefs in a position to win comfortably on Sunday Night Football."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Colts vs Chiefs picks, predictions, odds for NFL Week 2 game Sunday
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