The USC Trojans and Penn State Nittany Lions play on Saturday, Oct. 10, 2026, at Beaver Stadium in University Park, Pennsylvania, in a game on the college football Week 6 schedule.
Which team will win the college football Week 6 game?
Check out these college football Week 6 picks and college football Week 6 predictions for the game, which can be seen at 4:30 p.m. MST on NBC (stream with FUBO).
Penn State is a 2-point favorite over USC in college football Week 6 odds for the game, according to BetMGM Sportsbook.
The Nittany Lions are -120 on the moneyline, while the Trojans are +100. The over/under (point total) for the game is set at 54.5 points.
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Sporting News: USC 28, Penn State 27
Bill Bender writes: "How will the Trojans handle the 'Whiteout
'? How much juice will the Nittany Lions have after back-to-back losses? These are real questions for the Big Ten showdown. Penn State averages 83.5 rushing yards per game in conference play. USC is hardly trustworthy in cross-country games — but we still think they are the better team here. This is a huge game under Lincoln Riley."
Bookies.com: Bet USC on the moneyline vs Penn State
Bill Speros writes: "Matt Campbell and Penn State dropped their first two Big Ten games. Now Campbell must keep his team both focused on the field and away from the portal. The Nittany Lions offer a case study in how not to build an offense through the portal. Our model flips this line, favoring the Lions by 1.5 points in Not-So-Happy Valley. But we're not buying. These teams are a combined 0-6 ATS against Power Four opponents. The Trojans benefited from a front-loaded home schedule (and one road game, at Rutgers), and the night kick here helps offset the East Coast travel. USC's offense with Jayden Maiava is genuinely dangerous when it's clicking. Expect it to click here. This is a 'Whiteout' game for the Lions — but expect those white shirts to morph into white flags."
Dimers.com: Penn State 28, USC 27
It writes: "The numbers give Southern California a win probability of 48.9%, while Penn State jas a win probability of 51.1%."
ESPN: Penn State has a 62% chance to defeat USC
The site gives the Trojans a 38% shot at winning the college football Week 6 game.
Sports Betting Dime: Penn State 27.8, USC 18.5
The site's formula predicts that the Nittany Lions will beat the Trojans in the Week 6 college football game.
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: USC vs Penn State picks, predictions, odds for Week 6 game Saturday
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