Who will win on Wednesday night football in NFL Week 1?
The New England Patriots and Seattle Seahawks play on Wednesday, Sept. 9, at the Seahawks' Lumen Field in a game on the NFL Week 1 schedule.
What do NFL Week 1 odds say about the NFL season opener? Who are NFL Week 1 predictions and NFL Week 1 picks taking in the game?
Which team has the best chance to win the game according to NFL Week 1 win probabilities
?Check out The Arizona Republic's score prediction for the Wednesday night football game, as well as Patriots vs Seahawks picks, odds and win chances for the NFL Week 1 game, which can be seen at 5:20 p.m. MST on NBC (stream with Peacock).
NFL Week 1 predictions: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals
| Saints vs Lions | Bills vs Texans | Ravens vs Colts | Browns vs Jaguars | Falcons vs Steelers | Jets vs Titans | Cardinals vs Chargers | Dolphins vs Raiders | Packers vs Vikings | Commanders vs Eagles | Cowboys vs Giants | Broncos vs Chiefs | Picks, win probabilities
Watch Patriots at Seahawks on Peacock
NFL Week 1 prediction for Seahawks vs Patriots game
The Arizona Republic is predicting a 24-21 win for the Seahawks over the Patriots in the NFL Week 1 game on Wednesday.
Jeremy Cluff writes: "The Patriots would love to get a little revenge for their Super Bowl loss to the Seahawks. The problem is, Seattle is playing at home, where it has the 12th Man. Sam Darnold will do enough to lead the champions to a season-opening win."
NFL Week 1 picks for Patriots vs Seahawks game
Will the Seahawks or Patriots win the season opener in NFL Week 1?
Bookies.com says to bet the Patriots on the moneyline vs. the Seahawks.
Sports Betting Dime's formula predicts a 21.5-20.6 win for the Seahawks over the Patriots.
Dimers.com's final score prediction? Seahawks 24, Patriots 21.
BetMGM is betting the under in the Seahawks vs Patriots game.
NFL Week 1 picks: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals | Saints vs Lions | Bills vs Texans | Ravens vs Colts | Browns vs Jaguars | Falcons vs Steelers | Jets vs Titans | Cardinals vs Chargers | Dolphins vs Raiders | Packers vs Vikings | Commanders vs Eagles | Cowboys vs Giants | Broncos vs Chiefs | The Republic's predictions
NFL Week 1 win probabilities for Seahawks vs Patriots game
The Seahawks have a 61.1% chance to beat the Patriots on Wednesday, according to ESPN.
The site gives the Patriots a 38.6% shot at winning the NFL Week 1 game, with the remaining percentage accounting for a tie.
NFL Week 1 odds for Patriots vs Seahawks game
The Seahawks are a 3.5-point favorite over the Patriots in NFL Week 1 odds for the game, courtesy of BetMGM Sportsbook.
Seattle is -200 on the moneyline, while New England is +160.
The over/under (point total) is set at 44.5 points.
NFL Week 1 odds: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals | Saints vs Lions | Bills vs Texans | Ravens vs Colts | Browns vs Jaguars | Falcons vs Steelers | Jets vs Titans | Cardinals vs Chargers | Dolphins vs Raiders | Packers vs Vikings | Commanders vs Eagles | Cowboys vs Giants | Broncos vs Chiefs | Point spreads, moneylines, over/unders
NFL's highest paid players in 2026: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Overall | By position | By team
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Seahawks vs Patriots predictions, picks, odds for NFL Week 1 Wednesday
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