The Miami Hurricanes and Clemson Tigers play on Saturday, Oct. 3, 2026, at Memorial Stadium in Clemson, South Carolina, in a game on the college football Week 5 schedule.
Which team will win the college football Week 5 game?
Check out these college football Week 5 picks and college football Week 5 predictions for the game, which can be seen at 4:30 p.m. MST on ABC (stream with FUBO).
Miami is a 16.5-point favorite over Clemson in college football Week 5 odds for the game, according to BetMGM Sportsbook.
The Hurricanes are -800 on the moneyline, while the Tigers are +600. The over/under (point total) for the game is set at 48.5 points.
Watch Miami vs Clemson on FUBO (free trial)
Sporting News: Miami 34, Clemson 21
Bill Bender writes: "Is this Clemson's last stand? The Hurricanes bring
a high-scoring offense into Death Valley led by Darian Mensah – who leads the ACC with an 88.7% completion percentage. The Tigers had a 13-point home loss to Syracuse last season. The Tigers lack the explosive passing game to get into a track meet, so they will have to slow the game down with running back Gideon Davidson – who has 346 rushing yards on 5.9 yards per carry. Will Heldt – who leads the ACC with four sacks – also needs to have a game."
Bookies.com: Bet Miami to cover vs Clemson
Bill Speros writes: "The Hurricanes reign/rain as the lone ACC team ranked in the top 20. The ACC champion is guaranteed a playoff spot, but it's a coin toss after that. Miami can't afford to let up in conference play. The issue here is which version of the Hurricanes decides to show up in Mini-Death Valley in prime time: the team that hung 45 on Stanford, or the one that felt heat for three quarters at Wake Forest. Our model has Miami (2-1 ATS) winning by 18.4 points off a 17.5-point line. Miami's personnel overwhelm in the fourth quarter, and Mario Cristobal nabs the three-score cover late."
Dimers.com: Miami 33, Clemson 17
It writes: "After extensive simulations, our model gives Miami Florida a win probability of 88%, while Clemson has a win probability of 12%."
ESPN: Miami has an 87.4% chance to defeat Clemson
The site gives the Tigers a 12.6% shot at winning the college football Week 5 game.
Sports Betting Dime: Miami 24.3, Clemson 19.1
The site's formula predicts that the Hurricanes will beat the Tigers in the Week 5 college football game.
Picks and Parlays: Bet Miami to cover vs Clemson
Kim Smith writes: "Miami gets the side selection despite having to lay a substantial number on the road. The Hurricanes have shown considerably more consistency through the first month and enter this matchup after a 49-point victory. Clemson has home-field advantage and plenty of motivation, but the Tigers have already shown that they can struggle badly against elite competition. Miami’s ability to generate separation on both sides of the ball makes the Hurricanes the preferred side."
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Miami vs Clemson picks, predictions for college football Week 5 game
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