The Oklahoma State Cowboys and Houston Cougars play on Saturday, Oct. 17, 2026, at TDECU Stadium in Houston, Texas, in a game on the college football Week 7 schedule.
Which team will win the college football Week 7 game?
Check out these college football Week 7 picks and college football Week 7 predictions for the game, which can be seen at 4:30 p.m. MST on FOX. (stream with FUBO).
Houston is a 4-point favorite over Oklahoma State in college football Week 7 odds for the game, according to BetMGM Sportsbook.
The Cougars are -185 on the moneyline, while the Cowboys are +150. The over/under (point total) for the game is set at 61.5 points.
Watch Oklahoma State vs Houston on FUBO (free trial)
The Arizona Republic: Oklahoma State 35, Houston 31
Jeremy Cluff writes: "Oklahoma State has won four straight since
its season-opening debacle against Tulsa. The upset over Oregon has lost some of its luster for the Cowboys, but Drew Mestemaker and company can spring another upset over the Cougars in Houston to move to 3-0 in Big 12 play."
Bookies.com: Bet Houston to cover vs Oklahoma State
Bill Speros writes: "A loss here ends Houston's hopes for a Big 12 title game berth and CFB Playoff spot. The Pokes rank among the biggest surprises on the upside in college football this season thanks to a win over Oregon. This is the first of two major Big 12 challenges for Oklahoma State. It plays Texas Tech next month. OSU has won four straight and sits 4-1 ATS. Our model sits on this line, favoring Houston by 4.3 points. Houston's balanced offense (4 TD passes; 233 yards rushing, led by Re'Shaun Sanford's 90, at K-State) overwhelms OSU here, despite the Cougars owning the weakest 'home field advantage' in all of sports."
Dimers.com: Houston 32, Oklahoma State 28
It writes: "The numbers give Oklahoma State a win probability of 36.7%, while Houston has a win probability of 63.3%."
ESPN: Houston has a 74.9% chance to defeat Oklahoma State
The site gives the Cowboys a 25.1% shot at winning the college football Week 7 game.
Sports Betting Dime: Houston 28.9, Oklahoma State 27.1
The site's formula predicts that the Cougars will beat the Cowboys in the Week 7 college football game.

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Oklahoma State vs Houston picks, predictions, odds for Week 7 game
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